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A complete list of all postgraduate courses autumn 2007


1131Laboratory Animal Science
1156Populärvetenskaplig kommunikation
1201Apoptosis: Theory and Methods
1202Human Cell Culture. Methods and Applications
1380To communicate science (*)
1381To communicate science (*)
1382Att kommunicera vetenskap (*)
1383Basic Course in Medical Statistics (*)
1384Grundkurs i medicinsk statistik (*)
1385Grundkurs i medicinsk statisti (*)
1392Vetenskapligt skrivande och informationskompeten (*)
1393Writing science and information literacy (*)
1470Cytoplasm and Signal Transduction
1472 Infections in the tropics
1490Neurotransmitters and their receptors: Molecular biological techniques
1492Introduction to Proteomics
1496Flow cytometry: from theory to application
1507Rörelseapparaten klinisk utvärdering av funktion och behandling
1518Neuroendocrinology
1519Sensory mechanisms
1533Bioinformatics -- Introduction and practial applications
1551Cardiovascular research 2. An overview of the process of atherosclerosis
1575Principles of transcriptional networks in metabolic disease and cancer
1577Epidemiology I: Introduction to epidemiology
1579Biostatistics I: Introduction for epidemiologists
1583Genomic and Proteomic Methods and their Application in Medical Research
1584Alzheimers Disease: Clinical Features and Pathogenic Mechanisms
1590Cell cycle and apoptosis in cancer
1595Molecular Immunology
1598General mechanisms for inflammatory and allergic reactions
1601Methodologies in Clinical Research
1610gMalaria
1610hTuberculosis and other bacterial infections
1610iHIV and other viral infections
1627Clinical and experimental neuroimmunolgy
1642DNA-Proteins interactions in vivo: Gene regulation, factor binding and chromatin remodeling
1658From stress to disease: an integrated view
1659Health Policy and Management
1669Ischemic heart disease: from bedside to experimental models
1678The Global Diabetes Epidemic
1684Epidemiology III: Analysis and interpretation of data
1685Biostatistics III: Survival analysis for epidemiologists
1686How to Write and Publish a Scientific Paper in English (*)
1711Data collection and data analysis II (*)
1734Research strategies and design problems in caring sciences
1738The ubiquitin-proteasome system in health and disease
1741Cytostatic Drugs in Research and Cancer Treatment
1744Developmental Biology
1766Social Innovation and Entrepreneurship
1794Studiedesign vid klinisk forskning
1814The Methods for Qualitative Content Analysis
1823From genome to global malaria: diversity and control
1838Ideation Creating a Business Idea
1839Planning - Developing a Venture
1840Business Opportunities in ICT
1844Methodologies in Molecular Medicine
1845Basic course in International Health, focussing on field survey method
1846Improving drug use, especially antibiotics
1873Quality of life as an outcome measure in care sciences
1874International Classification of Functioning, Disability and Health
1887Physiology and Pharmacology III: Cardiovascular, Pulmonary and Muscle Physiology and Pharmacology
1896Execution Running Your Own Company
1899Growth Managing your Firm
1900Proteomics in cancer research
1921Astma, allergi och eksem i arbetslivet
1930Global Entrepreneurial Leadership
1931Languages of Innovation and Entrepreneurship
1935Neuropsychopharmacology of schizophrenia
1999Embryology I
2000Advanced seminars in Tumor Biology IV
2001What is life? The future of biology: IV
2003Ekonomiska utvärderingar av medicinska teknologier (Economic evaluations of medical technologies)
2009Datahantering och data analys med SPSS-syntax
2010Konsekvenser av modellval och antaganden vid kvantitativ datanalys
2022Basal immunologi för kliniska forskare
2023Experimental laboratory animal genetics
2026Problem based overview of medical statistics (*)
2034Injury Surveillance and Coding
2041Introduction to Stata for epidemiologists (*)
2044Pathology (#)
2059Innovation and technology management
2060Innovation in practice - Medical technology
2066Introduktion i neuropsykologi från ett tvärdisciplinärt perspektiv
2077Statistical analysis of questionnaires by Item Response Theory(*)
2080Qualitative interviews in hearing speech and language research
2081Statistical modelling using R (*)
2090Posttranslational modification of proteins
2091Natural Killer Cells: Immunology, Genetics and Diseases
2093Understanding developmental aspects of gastrointestinal malignancies
2094Receptor-mediated toxicity
2095How to write a successful grant application (*)
2097Aktuell omvårdnadsvetenskap – teori och praxis
2099Statistics in risk assessment focusing on dose response modelling (*)
2100Cell and molecular biology for dentists
2101Hörsel- och kommunikationsforskning: Att samverka med samhället
2102The mitochondrion: structure, function and its role in pathology and ageing
2104How genes meet environment: genetics of human complex diseases
2105Speech and Hearing Physiology: from Organ till Cortex
2106Toxicology I
2107Causal Inference from Longitudinal Data
2110Inherited cancer syndromes; genes predisposing to malignant disease, diagnosis, carcinogenesis and cancer prevention
2111Introduction to Medical Anthropology
2112Endothelial function in autoimmune related Human Atherosclerosis
2113Mucosal immunity and infections
2114Longitudinal Studies with Qualitative Approach
2115Person based quantitative designs in longitudinal research
2116Neurooftalmologi / Neuroophthalmology
2117Commercialising Science Innovation and Entrepreneurship Theory
2118Commercialising Science Innovation and Entrepreneurship Projects
2119Antigen presentation pathways and immune evasion
2120Infection and Cancer research seminar series
2125Hypertension - pathophysiology and treatment
2127Physiological Methods in Cardiovascular Research in Man
2128Development of the nervous system
2129Introduction to Protein Structure

Laboratory Animal Science

Course Number:1131

Credit Points:4,5

Date:10 sep 2007--21 sep 2007

All practical sessions, all group works and some of the lectures are compulsory. Missed parts can be completed after agreement with Veterinary Resources.

Course organizer:
Solveig Tjäder, MScVM
University Administration
Veterinary Resources
veta@admin.ki.se

Course leader:
Vera Baumans

Contact person:
Juha Halonen, PhD
University Administration
Veterinary Resources
Phone +46 8 524 800 00
Fax:08-33 92 47

Aim:
The course teaches the basic knowledge and principles of laboratory animal science. These are essential for the humane use and care of animals, and to ensure a high quality of research. This course qualifies you for a FELASA C-level certificate which is for researchers who design and direct their own animal experiments.

Contents:
The course contents are in accordance with recommendations from the Federation of European Laboratory Animal Science Associations (FELASA) and with the European legislation. Contents include introduction to laboratory animal science, design of animal experiments, legislation, laboratory animal genetics, behaviour, stress and homeostasis, allergies and other health hazards, gnotobiology, nutrition, animal welfare, environment and experimental procedures, transgenic technologies, alternatives to animal use, good laboratory practice, microbiology disease, preventions of infections, anaesthesia, surgery, euthanasia, ethics, animal protection. Demonstrations/laboratory sessions (in smaller groups): Techniques for handling and restraint, injection, sampling and anaesthesia (rabbit, rat, mouse). Additionally, students will prepare an experimental protocol and analyse a scientific paper. A

Populärvetenskaplig kommunikation

Course Number:1156

Credit Points:7,5

Date:10 sep 2007--14 jan 2008

Kursens obligatoriska moment är -Skrivövningar, I Notis, II Artikel och III en Notis som vänder sig till barn. -Redaktionsplacering med skriftlig och muntlig presentation. -Obligatoriska föreläsningar är Populärvetenskap Nytta och nöje, Intervjuteknik, Att skriva en artikel, Retorik Presentationsteknik, Får man skriva vad man vill i tidningen. -Besök på Sveriges Radio. -Redovisning av redaktionsplaceringar. Vid missat moment finns möjlighet att kompensera med projektarbete.

Course organizer:
Carl Johan Sundberg
Institutionen för Fysiologi och Farmakologi
Institutionen för Fysiologi och Farmakologi
carl.j.sundberg@ki.se


Contact person:
Marie-Louise Sundin
Institutionen för Fysiologi och Farmakologi
Institutionen för Fysiologi och Farmakologi
Phone -
Fax:+46 8 7090911

Aim:
Kursens syfte är att skapa intresse för och förmåga till att sakligt förmedla betydelsen av komplicerade vetenskapliga sammanhang på ett för mottagaren stimulerande sätt.

Contents:
Kursen är, förutom föreläsningar av ledande vetenskapsjournalister, uppbyggd kring tre skrivövningar med individuell feed-back från vetenskapsjournalister och en redaktionsplacering, 10 dagar (främst dagtid). Redaktionsplaceringen utförs i samverkan med handledare med stor erfarenhet och kompetens i medicinsk/vetenskaplig journalistik.

Apoptosis: Theory and Methods

Course Number:1201

Credit Points:1,5

Date:26 nov 2007--30 nov 2007

Course organizer:
Boris Zhivotovsky
Institute of Environmental Medicine
Division of Toxicology
Boris.Zhivotovsky@ki.se


Contact person:
Boris Zhivotovsky
Institute of Environmental Medicine
Division of Toxicology
Phone
Fax:+46 8 32 90 41

Aim:
The aim of the course is to provide a small number of graduate students with a detailed knowledge of the principles and methods currently guiding research in cell death (apoptosis).

Contents:
Theoretical: The lectures will open with an introduction to cell death and an examination of the relative significance of apoptosis in biology and medicine. They will then discuss the latest results available on (i) molecular mechanisms of cell death, (ii) regulators of cell death and survival, (iii) role of different intracellular compartments in apoptosis, (iv) role of proteases in apoptosis, (v) phagocytosis in apoptosis, (vi) inducers of apoptosis, with particular emphasis on anti-cancer chemotherapy, (vii) inhibitors of apoptosis, with particular emphasis on therapeutic strategies for neurodegenerative disorders, (viii) apoptosis in immune system, (ix) relevance to toxicology, (x) oxidative stress and apoptosis, (xi) apoptosis and cell cycle regulation, (x) methods for detection of apoptosis.
Practical: The students will work through 5 projects during the week. (1) Assessment of cell viability. (2) Assessment of apoptosis by examination of the nucleus (morphology, chromatin degradation). (3) Analysis of apoptosis by FACS. (4) Analysis of protease activation. (5) Analysis of mitochondrial changes

Human Cell Culture. Methods and Applications

Course Number:1202

Credit Points:1,5

Date:20 aug 2007--24 aug 2007

Lectures, laboratory activities and final group oral examination

Course organizer:
Roland Grafström
Institute of Environmental Medicine
Biochemical Toxicology and Experimental Cancer Research
roland.grafstrom@ki.se


Contact person:
Roland Grafström
Institute of Environmental Medicine
Biochemical Toxicology and Experimental Cancer Research
Phone +46 8 524 875 99
Fax:468342810

Aim:
To provide basic and state-of-the-art methods in cell culture techniques. To provide lectures and to stimulate discussions concerning the theory and practice of cell culture. To provide guidance and training in bench work with cell cultures on an individual basis. The participants should preferably have some previous experience in cell culture

Contents:
Cell culture reflecting stem, transit amplifying, differentiated and terminally differentiated tissue states; Monolayer and organotypic culture involving one or more cell types. Applicability of cell cultures as alternatives to laboratory animal experiments. Mechanisms regulating cell growth and viability, differentiation and apoptosis. Assessment of cell transformation to immortal and malignant phenotypes. Isolation of specific cells, e.g., epithelial cells,characterisation of cultured cells. Handling and sterile techniques, choice of materials and media for cell culture, e.g., serum-dependent vs. serum-free culture conditions. Cell cloning and gene transfer. Practical handling of cultures: thawing/freezing, passage, expansion and long-term storage. Handling of normal and tumor tissue for optimizing obtainment of cultures. Tissue engineering practices. Transcriptomics, proteomics and informatics methods for biomedical research with cell lines. Discussion of participants own culture experience and problems.

To communicate science (*)

Course Number:1380

Credit Points:1,5

Date:6 sep 2007--12 oct 2007

Dates of the course: 6+7/9, 27+28/9 and 11+12/10 Compulsory moments: 1.Oral presentation in a popular science context (video recorded) (day 3 or 4 of the course) 2.Written reflective statement based on theories of learning and understanding has to be handed in. 3.Oral presentation in a popular science context supported by PowerPoint (day 5 or 6 of the course)

Course organizer:
Lena Boman
Department of Learning, Informatics, Management, and Ethics LIME

lena.boman@ki.se


Contact person:
Margareta Krook-Brandt
Department of Learning, Informatics, Management, and Ethics LIME

Phone +46 8 524 87118
Fax:+46 8 34 51 28

Aim:
The overall aim of the course is to enhance communication in teaching, research and popular science contexts.

Contents:
During the course you will be given the opportunity to develop practical and theoretical knowledge in:
Communication and learning
Presentation techniques
Rhetoric
Use of different media (such as Posters, Overhead-projector, PowerPoint, Whiteboard)

Each course participant will give two oral presentations, after which there will be feedback on content, communication skills, body language and use of media.

To communicate science (*)

Course Number:1381

Credit Points:1,5

Date:18 oct 2007--15 nov 2007

Dates of the course: 18+19/10, 31/10+1/11 and 14+15/11 Compulsory moments: 1.Oral presentation in a popular science context (video recorded) (day 3 or 4 of the course) 2.Written reflective statement based on theories of learning and understanding has to be handed in. 3.Oral presentation in a popular science context supported by PowerPoint (day 5 or 6 of the course)

Course organizer:
Lena Boman
Department of Learning, Informatics, Management, and Ethics LIME

lena.boman@ki.se


Contact person:
Margareta Krook-Brandt
Department of Learning, Informatics, Management, and Ethics LIME

Phone +46 8 524 87118
Fax:+46 8 34 51 28

Aim:
The overall aim of the course is to enhance communication in teaching, research and popular science contexts.

Contents:
During the course you will be given the opportunity to develop practical and theoretical knowledge in:
Communication and learning
Presentation techniques
Rhetoric
Use of different media (such as Posters, Overhead-projector, PowerPoint, Whiteboard)

Each course participant will give two oral presentations, after which there will be feedback on content, communication skills, body language and use of media.

Att kommunicera vetenskap (*)

Course Number:1382

Credit Points:1,5

Date:30 aug 2007--4 oct 2007

Kursens datum: 30+31/8, 19+20/9 och 3+4/10 Obligatoriska moment: 1.Muntlig presentation i ett populärvetenskapligt sammanhang (videoinspelning) (dag 3 eller 4 under kursen) 2.Skriftlig reflektion baserad på teorier om lärande och förståelse ska lämnas in. 3.Muntlig presentation i ett populärvetenskapligt sammanhang med stöd av PowerPoint (dag 5 eller 6 under kursen)

Course organizer:
Lena Boman
Department of Learning, Informatics, Management, and Ethics LIME

lena.boman@ki.se


Contact person:
Margareta Krook-Brandt
Department of Learning, Informatics, Management, and Ethics LIME

Phone +46 8 524 87118
Fax:+46 8 34 51 28

Aim:
Syftet med kursen är att kursdeltagarna skall utveckla sin förmåga att kommunicera muntligt i undervisnings-, forsknings- och populärvetenskapliga sammanhang.

Contents:
Under kursen ges du möjlighet att utveckla praktisk och teoretisk kunskap om:
-Kommunikation och lärande
-Presentationsteknik
-Retorik
-Användande av olika hjälpmedel (dvs. Poster, Overhead, PowerPoint, White-Board)
Varje kursdeltagare utför under kursen två muntliga presentationer som följs upp med återkoppling på innehåll, kommunikationsförmåga, kroppsspråk och användande av hjälpmedel.

Basic Course in Medical Statistics (*)

Course Number:1383

Credit Points:3

Date:10 sep 2007--26 sep 2007

2007-09-10-2007-09-12, 2007-09-17-2007-09-19, 2007-09-24-2007-09-26 The course will consist of three scheduled half or whole days per week for three weeks. Lectures will be mixed with seminars and manual exercises. The rest of the time will be spent working on computer based homework and reading the course literature. -Correct answers on the exercises. -Active participation in the seminars and manual exercises.

Course organizer:
Anna Wiklund
Department of Learning, Informatics, Management and Ethics
Medical Statistics
Anna.wiklund@ki.se


Contact person:
Margareta Krook-Brandt
Department of Learning, Informatics, Management and Ethics
Medical Statistics
Phone +46 8 524 871 18
Fax:+46 8 34 51 28

Aim:
The aim of the course is to provide knowledge of basic medical statistics.

Contents:
The course is an introduction to basic statistical principles and how statistics play a part in medical research. Concepts being treated are hypothesis, type I error, type II error, estimate, measurement of dispersion, regression analysis, inference making and how to present the results.

Grundkurs i medicinsk statistik (*)

Course Number:1384

Credit Points:3

Date:8 oct 2007--24 oct 2007

2007-10-08-2007-10-10, 2007-10-15-2007-10-17, 2007-10-22-2007-10-24 Undervisningen kommer att bestå av tre schemalagda halv-eller heldagar per vecka under tre veckor. Föreläsningar varvas med seminarier och manuella räkneövningar. Övrig tid ägnas åt arbete med datorbaserade hemuppgifter samt inläsning av kurslitteraturen. -Godkända övningar. -Aktivt deltagande i seminarierna och de manuella räkneövningarna.

Course organizer:
Anna Wiklund
Institutionen för lärande, informatik, management och etik (LIME)
Medicinsk statistik
Anna.wiklund@ki.se


Contact person:
Margareta Krook-Brandt
Institutionen för lärande, informatik, management och etik (LIME)
Medicinsk statistik
Phone +46 8 524 871 18
Fax:+46 8 34 51 28

Aim:
Kursens mål är att ge kunskaper i grundläggande medicinsk statistik.

Contents:
Introduktion av grundläggande statistiska principer och statistikens roll i medicinsk forskning. Hypotesprövning, fel av typ I och II, estimat, spridningsmått, konfidensintervall, regressionsanalys, konklusion och presentation av resultat behandlas.

Grundkurs i medicinsk statisti (*)

Course Number:1385

Credit Points:3

Date:12 nov 2007--28 nov 2007

2007-11-12-2007-11-14, 2007-11-19-2007-11-21, 2007-11-26-2007-11-28 Undervisningen kommer att bestå av tre schemalagda halv-eller heldagar per vecka under tre veckor. Föreläsningar varvas med seminarier och manuella räkneövningar. Övrig tid ägnas åt arbete med datorbaserade hemuppgifter samt inläsning av kurslitteraturen. -Godkända övningar. -Aktivt deltagande i seminarierna och de manuella räkneövningarna.

Course organizer:
Anna Wiklund
Institutionen för lärande, informatik, management och etik (LIME)
Medicinsk statistik
Anna.wiklund@ki.se


Contact person:
Margareta Krook-Brandt
Institutionen för lärande, informatik, management och etik (LIME)
Medicinsk statistik
Phone +46 8 524 871 18
Fax:+46 8 34 51 28

Aim:
Kursens mål är att ge kunskaper i grundläggande medicinsk statistik.

Contents:
Introduktion av grundläggande statistiska principer och statistikens roll i medicinsk forskning. Hypotesprövning, fel av typ I och II, estimat, spridningsmått, konfidensintervall, regressionsanalys, konklusion och presentation av resultat behandlas.

Vetenskapligt skrivande och informationskompeten (*)

Course Number:1392

Credit Points:3

Date:15 oct 2007--26 oct 2007

OBS! I kursen ingår en obligatorisk skrivuppgift som skall lämnas in ca. 10 dagar FÖRE kursens början. Instruktioner skickas till den e-postadress som uppgivits vid ansökan. Doktoranden ombeds kontakta kursledningen om informationen inte kommit fram 30 dagar före kursstart.

Course organizer:

David Herron
Karolinska Institutet Universitetsbiblioteket
david.herron@kib.ki.se


Contact person:
David Herron


Phone
Fax:

Aim:
Syftet med kursen är att utveckla deltagarens förståelse för den skiftliga vetenskapliga kommunikationsprocessen

Contents:
Scientific writing, Popular science writing, Grant writing, Thesis writing, Figures and tables, Revising structure and style, Ethical issues in writing, Publication process, Principer för medicinsk databassökning, Introduktion till referenshantering – Endnote, Tips och råd i Word, Evalueringsverktyg för medicinsk vetenskap, Open Access.
OBS! Vissa delar av kursen ges på engelska (listade på engelska ovan).

Writing science and information literacy (*)

Course Number:1393

Credit Points:3

Date:19 nov 2007--30 nov 2007

Note. The course includes an obligatory writing assignment which has to be submitted about 10 days BEFORE course start. Instructions about the assignment will be sent to the e-mail address given by the course applicant. Participants are requested to contact the course leaders if they have not received these instructions 30 days before course start.

Course organizer:
David Herron
Karolinska institutet Universitetsbiblioteket

david.herron@kib.ki.se


Contact person:
David Herron


Phone
Fax:

Aim:
The aim of the course is to develop the participant’s understanding of the written scientific communication process

Contents:
Scientific writing, Popular science writing, Grant writing, Thesis writing, Figures and tables, Revising structure and style, Ethical issues in writing, Publication process, Principles of medical information retrieval, Getting started with reference management – Endnote, Tips and tricks with Word, Literature evaluation tools for the medical sciences, Open Access.

Cytoplasm and Signal Transduction

Course Number:1470

Credit Points:3

Date:5 nov 2007--16 nov 2007

Introductory lectures and discussions are obligatory. Absence from the introductory lectures and discussions or tutorials is compensated according to the instructions of the course leader.

Course organizer:
Björn Öbrink
Department of Cell and Molecular Biology

bjorn.obronk@ki.se

Course leader:
Björn Öbrink/Cell och molekylärbiologi


Contact person:
Inger Westin Jonsson
Department of Cell and Molecular Biology
Molecular Cell Biology
Phone 08-524 873 71
Fax:+46 8 313529

Aim:

The course presents signal transduction in a wide perspective, focusing on three selected areas in cell biology: regulated proteolysis, cell adhesion and signal regulation by cell adhesion molecules and, angiogenesis.

Contents:
The following topics will be treated: Regulated proteolysis; Cell adhesion and signal regulation by cell adhesion molecules; Angiogenesis. The topics will be introduced and reviewed in introductory lectures by the teachers. The students will be given key original papers, which will be penetrated in depth and discussed together with the teachers. Emphasis will be put on hypotheses, concepts and methodology. The course will end with oral presentations by the students. It is important to understand that participation in the course means full time engagement during a two weeks period, during which each student will devote a substantial amount of time in studying and penetrating original research literature.

It should be emphasized that a prerequisite for being accepted to the course is that the applicants must submit with their application 1) a short, clear and informative description of their PhD research project, 2) name and affiliation of their scientific supervisor/group leader, and 3) their own institutional affiliation.

Infections in the tropics

Course Number:1472

Credit Points:7,5

Date:1 dec 2007--7 jan 2008

First three weeks in Africa compulsory participation of all moments including night duty attendances. Fourth week preparation of elective project. Fifth week presentation of elective projects, complementary lectures and exam, all compulsory

Course organizer:
Sven Britton
Dept Medicine
Div. Infectious Diseases
sven.britton@ki.se

Course leader:
Hannah Akuffo, PhD and Ulf Bronner, MD,PhD

Contact person:
Sven Britton
see above
see above
Phone see above
Fax:+46 8 51771806

Aim:
To be made familiar with the conditions under which the major infectious diseases in the Tropics arise and how they are prevented/treated locally. To be acquainted with the conditions for biomedical research in the tropics and be exposed to some of the current local research projects.

Contents:
Field studies under local and Swedish faculty at the primary, secondary and tertiary health care levels. Visit to local research institute with mutual seminars on research projects. Formulation and presentation of elective project.

Neurotransmitters and their receptors: Molecular biological techniques

Course Number:1490

Credit Points:1,5

Date:19 nov 2007--23 nov 2007

All laboratory work, lab report and examination are compulsary. The laboratory work can unfortunatly not be compensated by an other occasion but If any student will miss the day of examination depending on a reasonable case, he/ she will be given an other chance to do the examination.

Course organizer:
Malahat Mousavi
Neurobiology, Care Science & Society
Division of Molecular neuropharmacology
malahat.mousavi@ki.se

Course leader:
Zhi-Zhong Guan, Division of Molecular Neuropharmacology, Neurotec
Malahat Mousavi, Division of Molecular Neuropharmacology, Neurotec

Contact person:
Malahat Mousavi
Neurobiology, Care Science & Society
Division of Molecular neuropharmacology
Phone +46-8-585 83 612
Fax:+46 8 58583860

Aim:
To provide graduate students the basic knowledge in this field of neuroscience. Introduction to give basic knowledge in molecular biology and recombinant techniques. Principal applications of different molecular biological techniques such as RNA isolation and measurement, in situ hybridization, RT-PCR, Real-time PCR. Some previous knowledge in biological chemistry, molecular biology and pharmacology is desired.

Contents:
Full time for one week, including lectures (30%), laborations and some demonstrations (70%)

Introduction to Proteomics

Course Number:1492

Credit Points:5

Date:19 sep 2007--5 dec 2007

Group discussions are compulsory

Course organizer:
Jan-Olov Höög
Dep of Medical Biochemistry and Biophysics
Chemistry I
jan-olov.hoog@ki.se

Course leader:
Jan-Olov Höög
Gunter Schneider
Karl Tryggvason


Contact person:
Eva Lindberg
Dep of Medical Biochemistry and Biophysics
Molecular Structural Biology
Phone +46 8 524 876 76
Fax:+46 8 338453

Aim:
The aim of this course is to broadly introduce the field of proteomics in the form of lectures and group discussions headed by leading domestic and foreign scientists. The lectures will elucidate how scientists approach a large variety of questions related to proteomics and protein function from a variety of angles. Thus, the lecture topics will span a broad range, representing areas such as molecular epidemiology, molecular genetics, molecular and cellular biology, developmental biology, protein chemistry, bioinformatics, structural biology, and approaches to the development of novel drugs based on protein function.

Contents:
The course consists of 12 weeks of double lectures. Each lecture event includes a basic lecture for graduate students and in some cases a more regular scientific lecture. After the lectures the lecturer will have a discussion with a group of about 10 graduate students who can present and discuss their own projects or research in general. Each participant will have an opportunity to participate in 2-3 group discussions. Prior to each lecture, the lecturer will provide the participants with research article/s related to the lecture topic.

The lectures will take place every Wednesday afternoon the fall semester 2007.

Flow cytometry: from theory to application

Course Number:1496

Credit Points:1,5

Date:16 oct 2007--20 oct 2007

The course is one week full time, consisting of 28 hr lectures, 10 hr laboratory work, and 2 hr group work.

Course organizer:
Nailin Li
Department of Medicine, Karolinska University Hospital (Solna)
Division of Clinical Pharmacology
Nailin.Li@ki.se

Course leader:
Helene Stridh, Cancer Centrum Karolinska, Karolinska University Hospital (Solna)

Contact person:
Nailin Li
Department of Medicine
Division of Clinical Pharmacology Unit
Phone +46 8 5177 3996
Fax:+46 8 313 343

Aim:
To introduce the principles of flow cytometry.
To introduce the major applications of flow cytometry in biomedical research.

Contents:
The course covers basic knowledge and main applications of flow cytometry, and contains both lectures and laboratory/group work. Experts in different fields of flow cytometric application are invited to give the lectures.
The participants will be able to learn:
a) Principles of flow cytometry: working mechanisms of flow cytometer; molecular and cellular probes for flow cytometry; quality control; and safty procedures and intrument maintainance.
b) Basic skills: flow cytometric protocol design; sample handling and storage; data processing and analysis, and data presentation.
c) Major applications of flow cytometry in biomedical research: leukocyte phenotyping, endothelial cell analysis, stem cell analysis, apotosis, platelet and platelet-leukocyte aggregate measurement, cell function analysis (including membrane potential, oxidative metabolism, intracellular calcium mobilization, pH, and intracellular organelles), as well as nucleic acid analysis.

Rörelseapparaten klinisk utvärdering av funktion och behandling

Course Number:1507

Credit Points:1,5

Date:15 oct 2007--19 oct 2007

Inga

Course organizer:
Lars Weidenhielm
Inst för molekylär medicin och kirurgi
Sektionen för ortopedi och idrottsmedicin
lars.weidenhielm@karolinska.se

Course leader:
Per Wretenberg, Inst. för Molekylär medicin och kirurgi (K1), Sekt för ortopedi

Contact person:
Annika Kling Österlund
Inst för molekylär medicin och kirurgi
Sektionen för ortopedi och idrottsmedicin
Phone +46 8 517 727 20
Fax:46857175778

Aim:
Att bibringa kursdeltagaren kunskaper om metoder inom forskningen kring rörelseorganens sjukdomar och skador samt kunskaper om hur man lägger upp och genomför ett kliniskt forskningsprojekt inom detta område.

Contents:
Klinisk utvärdering av funktion och behandling inom rörelseorganens sjukdomar och skador.

Neuroendocrinology

Course Number:1518

Credit Points:1,5

Date:10 sep 2007--14 sep 2007

Students should attend all lectures

Course organizer:
Per Södersten
NVS
Section of applied neuroendocrinology
per.sodersten@ki.se


Contact person:
Per Södersten
See above

Phone
Fax:+46 8 55640610

Aim:
Understanding of the principles of hormone secretion by the nervous system and hormone action on the nervous system in relation to the display of behaviour, the regulation of homeostatic functions and the pathophysiology of illness

Contents:
Neurosecretion, mechanisms of hormone action, neuroanatomy of motivated behavior, genetics of behavior, neuroendocrine control of reward, circadian rhythms, physical activity, energy metabolism, sex, thirst, eating and body weight in health and disease>

Sensory mechanisms

Course Number:1519

Credit Points:3

Date:12 nov 2007--23 nov 2007

Seminars, Demonstrations and practicals

Course organizer:
Barbara Canlon
Physiology and Pharmacology
Physiology
barbara.canlon@ki.se

Course leader:
Barbara Canlon, Physiology & Pharmacology

Contact person:
Barbara Canlon
Physiology and Pharmacology
Physiology and Pharmacology
Phone
Fax:+46 8 32 70 26

Aim:
To understand the sensory systems and attain insight into present methodology and research problems on a graduate level.

Contents:
The course will cover general mechanisms for transduction of stimuli to electrical signals in different sensory systems. Central information processing and integration will be treated and efferent control of sensory systems. Mechanosensory systems including those in the skin (tactile) and for motor control; auditory system, vision, chemical senses like taste and olfaction and aspects of pain. Additional systems can also be considered. The importance of higher functions in perception of sensory information will be treated. Students will present seminars in their own research fields.

Bioinformatics -- Introduction and practial applications

Course Number:1533

Credit Points:4,5

Date:2 oct 2007--18 dec 2007

Course organizer:
Bengt Persson
Dep of Cell and Molecular Biology
Genomic Structure and Integrity
Bengt.Persson@ki.se

Course leader:
Prof. Bengt Persson, Center for Genomics and Bioinformatics, KI

Contact person:
Eva Lindberg
Dep of Medical Biochemistry and Biophysics
Molecular Structural Biology
Phone +46 8 524 876 76
Fax:+46 8 338453

Aim:
To provide an introduction to bioinformatics and to give practical applications of bioinformatics in biomedical research.

Contents:
* Pairwise sequence comparisons
* Multiple sequence comparisons
* Databases
* SRS -- Sequence Retrieval System
* Sequence information and predictions
* Orientation about molecular modelling
* Evolutionary analyses

The course will consist of lectures (preferentially between 10:00 and 12:00) and exercises (preferentially between 13:00 and 16:00).

Cardiovascular research 2. An overview of the process of atherosclerosis

Course Number:1551

Credit Points:1,5

Date:15 oct 2007--19 oct 2007

Examination is compulsory. Absent students will be given special task to turn in on later occasion

Course organizer:
Gabrielle Paulsson-Berne
Department of Medicine, Solna
Experimental Cardiovascular Research
GabrielleBerne@ki.se

Course leader:
Gabrielle Paulsson Berne_Department of Medicine, Experimental Cardiovascular Research, CMM

Contact person:
See above
See above

Phone See above
Fax:+46 8 31 12 98

Aim:
To provide the students working in specific projects in the atherosclerosis field with in-depth views and up-to-date overview of current research of the pathology of atherosclerosis, with different operating mechanisms.

Contents:
Atherosclerosis will be discussed from the molecular, cellular, genetic, clinical and epidemiological viewpoints. Topics to be covered include discussions of the roles of the following in atherosclerosis: lipids and lipoproteins, oxLDL; thrombosis; plaque stability; inflammation; innate and adaptive immunity; proteinases; blood pressure; and diabetes/insulin resistance. Examples of in vitro and animal models as well as clinical studies will be discussed
This course is now considered as part (second course) of a block of 4 courses specially planned to give the PhD students in the area of Cardiovascular Research a continuous and non-overlapping education on the mechanisms of function of the vascular wall and its consequences to health and disease. Attendance to the whole block is advised and in this case the courses should preferably be attended in the order 1554-1551-1710-1669. For those who prefer, participation in single courses is also acceptable.

Principles of transcriptional networks in metabolic disease and cancer

Course Number:1575

Credit Points:1,5

Date:24 sep 2007--12 nov 2007

Course organizer:
Knut Steffensen
Department of Biosciences and Nutrition
Department of Biosciences and Nutrition
knut.steffensen@biosci.ki.se

Course leader:
Eckardt Treuter Department of Biosciences at NOVUM
Claes Gustafsson Department of Medical Nutrition at NOVUM

Contact person:
Kristina Bergholm
Department of Biosciences and Nutrition
Department of Biosciences and Nutrition
Phone +46 8 608 92 14
Fax:+46 8 774 55 38

Aim:
To give students an overview of the molecular mechanisms of regulated transcription in eukaryotic cells, in health and disease, with emphasis on the interplay between the basal transcription apparatus, coregulators and gene-specific transcription factors.

Contents:
Current research in the area of gene regulation, exploits functional genomics and molecular biology to understand the role of transcriptional networks in physiology and in metabolic (e.g. obesity, diabetes and metabolic syndrome) and proliferative (e.g. reproductive cancer, leukemia) disorders. The goal of this course is to present some of the latest and most exciting discoveries and methodological breakthroughs, in understanding transcriptional regulation including protein modifications, such as sumoylation and ubiquitination. The students will be given a broad overview of the field by attending lectures given by experts and international leading scientists, especially invited to cover various topics. The students will also be given a unique opportunity to join discussion groups with the lecturers during this course.

Epidemiology I: Introduction to epidemiology

Course Number:1577

Credit Points:1,5

Date:22 oct 2007--26 oct 2007

None.

Course organizer:
Anita Berglund
Institute of Enviromental Medicine

Anita.berglund@ki.se

Course leader:
Unnur Valdimarsdottir

Contact person:
Anita Berglund
Institute of Enviromental Medicine

Phone +46 8 524 874 66
Fax:+46 8 31 49 75

Aim:
The course aims to give an introduction to epidemiological theory and practice.

Contents:
his course presents an introduction to epidemiology as a research discipline.
The course introduces measures of disease occurrence, measures of causal effects, common designs for epidemiological studies (cohort study, case-control study) and their interpretation, the role of bias and confounding, and the concepts sensitivity and specificity.
The theories and concepts presented in lectures are applied, explored, and expanded upon in group exercises, group discussions, and reviews of scientific articles.

Biostatistics I: Introduction for epidemiologists

Course Number:1579

Credit Points:3

Date:19 nov 2007--7 dec 2007

Course organizer:
Paul Dickman
Department of Medical Epidemiology and Biostatistics

Paul.dickman@ki.se


Contact person:
Camilla Ahlqvist
Medical Epidemiology and Biostatistics

Phone +46 8 524 838 69
Fax:+46 8 31 49 75

Aim:
The course aims to introduce statistical concepts and methods with
emphasis on applications in epidemiology and public health.

Contents:
This course introduces classical statistical concepts and methods with emphasis on methods used in epidemiology and public health. Topics covered include: the importance of statistical thinking; types of data (nominal, binary, discrete and continuous variables); data summary measures; contingency tables; graphical representations; notions of probability; probability models (distributions); principles of statistical inference; parameter estimation (mean, proportion, prevalence, incidence and ratios); concepts of confidence intervals and hypothesis tests, both parametric and non-parametric; and a general introduction to linear regression models.

Genomic and Proteomic Methods and their Application in Medical Research

Course Number:1583

Credit Points:3

Date:10 sep 2007--21 sep 2007

All parts of the course are compulsory, especially the laboratory part. To compensate for absence, self-studies and an essay of the topic(s) missed must be performed.

Course organizer:
Gösta Eggertsen
1.Department of Laboratory Medicine 2.Center for Metabolism and Endocrinology
1.Division of Clinical Chemistry 2.Department of Medicine
gosta.eggertsen@karolinska.se

Course leader:
Mary Hunt Dep. of Laboratory Medicine, Karol. Univ. Hsp, Huddinge
Ingrid Dahlman Department of Medicine, Karol. Univ. Hsp, Huddinge
Vanessa van Harmelen Department of Medicine, Karol. Univ. Hsp, Huddinge

Contact person:
Jenny Bernström
Department of Laboratory Medicine
Division of Clinical Chemistry
Phone +46 8 585 90
Fax:46 8 585 812 60

Aim:
The students should get acquainted with some basic molecular biology techniques used in medical research

Contents:
The course is intended as an introductory course to molecular biology, focusing on analysis of gene and protein expression. It combines theoretical lectures and practical laboratory work.
The course, organized by the Division of Clinical Chemistry, Department of Laboratory Medicine, Karolinska University Hospital Huddinge in collaboration with the Center for Metabolism and Endocrinology, aims at giving an introduction to:
1.Genomic methods, i.e. analysis of nucleic acid expression (topics include: DNA, RNA, transcription, translation, restriction enzymes, cloning, sequence analysis, PCR, gene expression, microarray, pharmacogenetics) including practical experiments (RT-PCR cloning, real-time PCR, SNP analysis)
2.Proteomic methods, i.e. analysis of protein expression (topics include: characterization and separation of proteins, analytical approaches, mass spectroscopy, electrophoresis), including a practical experiment (Western Blotting).

Examples of how these methods can be used in medical research will be given during the course. In addition, bioinformatics and imaging techniques will also be discussed briefly.

Alzheimers Disease: Clinical Features and Pathogenic Mechanisms

Course Number:1584

Credit Points:1,5

Date:24 sep 2007--28 sep 2007

Written examination (28 Sept), if absent an alternative date will be set in October

Course organizer:
Eirikur Benedikz
Department of Neurobiology, Care Sciences and Society
Division of Neurodegeneration and Neuroinflammation
eirikur.benedikz@ki.se

Course leader:
Richard Cowburn
Maria Ankarcrona
Eirikur Benedikz
Marianne Schultzberg

Contact person:
Eirikur Benedikz
Department of Neurobiology, Care Sciences and Society
Division of Neurodegeneration and Neuroinflammation
Phone +46 8 585 838 92
Fax:+46 8 585 85470

Aim:
To provide up-to-date knowledge of different aspects of Alzheimers disease (AD) from clinical symptoms and diagnosis to molecular mechanisms and future perspectives.

Contents:
Lectures by invited Swedish and international scientists will cover the topics of clinical signs and symptoms, diagnosis, pathology, epidemiology, genetics, molecular mechanisms and animal models. Group seminars will cover demonstration of patients, neuropsychological analysis and neuroimaging.

Cell cycle and apoptosis in cancer

Course Number:1590

Credit Points:1,5

Date:24 sep 2007--28 sep 2007

Full time course. To compensate for possible absence, the student has to have a discussion with the course organizer.

Course organizer:
Galina Selivanova
MTC, C1
Selivanovas group
galina.selivanova@ki.se


Contact person:
Galina Selivanova
MTC
Selivanovas group
Phone +46 8 5248 6302
Fax:

Aim:
To learn about the role of mutations in cell cycle and apoptosis genes in cancer development

Contents:
Lectures on cell cycle, DNA damage checkpoints and its perturbation in cancer
Pro- and anti-apoptototic proteins in cancer and in cancer therapy
Oncogene activation as a driving force for cancer development and its targeting for cancer therapy
Tumor suppressors as targets for drug development
Proteolysis and cancer

Molecular Immunology

Course Number:1595

Credit Points:3

Date:28 nov 2007--11 jan 2008

Lectures, project work and the final student presentations are compulsory. Compensations for missed events may be possible after discussion with the cousre leader. The type of compensatory action will depend on the number of missed lectures. Possible actions include, but are not restricted to, a written exam, an essay or an oral exam.

Course organizer:
Petter Höglund
Department of Microbiology Tumor and Cell Biology (MTC)

petter.hoglund@ki.se

Course leader:
Petter Höglund

Contact person:
Petter Höglund
Department of Microbiology Tumor and Cell Biology (MTC)

Phone +46 8 524 862 01
Fax:+468304276

Aim:
To give an updated view on the most interesting areas of immunology, with special focus on current methodological aspects of immunological research.

Contents:
The course is given during 2 weeks. Invited national and international lecturers give their views on selected problems, or techniques, in immunology. The seminars take off from basic facts, but the speakers are encouraged to move on to current problems, and to focus on both scientific and methodological aspects. To merit 3 full ECTS points for the course, students will be asked, in a group project work, to study an immunological method or problem deeply at the theoretical level and lecture about this method to the fellow students. At the end of the course, a written and an oral presentation is expected from all students.

General mechanisms for inflammatory and allergic reactions

Course Number:1598

Credit Points:1,5

Date:23 oct 2007--27 oct 2007

Course organizer:
Jan Palmblad
Dept of Medicine, Huddinge, H7
Hematology and Centrum för allergiforskning
jan.palmblad@ki.se

Course leader:
Bengt Björkstén, Center for Allergy Research

Contact person:
Berit Lecomte
Dept of Medicine at Huddinge Campus, H7
Centrum för allergiforskning
Phone 46858586985
Fax:

Aim:
To give a basal overview of general mechanisms for inflammatory reactions including allergic inflammation.

Contents:
In vivo and in vitro methods for inflammation research, signal transduction in inflammatory cells, cytokine and chemokine networks, free radicals as mediators of inflammation. Organ-specific inflammatory reactions will also be included, i.e. in lungs, skin, joints and the vascular wall, as well as the induction of the allergic inflammation. One topic is to illustrate why exposure to molds under certain conditions cause a neutrophil inflammation and sometimes an IgE-mediated attack. Clinical and basic research issues will be equally approached. This one week coutse is divided in 3 days of lectures,1 day of seminars, 1 day of project work. The exam is in the format of a seminar, where participants describe and discuss chosen aspects of inflammation.

Methodologies in Clinical Research

Course Number:1601

Credit Points:1,5

Date:5 nov 2007--9 nov 2007

Presens at four days is compulsory, special reasons for absence for one day can be discussed.

Course organizer:
Professor Britt-Marie Landgren, Professor Outi Hovatta
Department for Clinical Science, Intervention and Technology (CLINTEC)
Division of Obstetrics and Gynecology, K57
britth-marie.landgren@karolinska.se,

Course leader:
Professor Outi Hovatta, Department for Clinical Science, Intervention and Technology (CLINTEC), Division of Obstetrics and Gynecology, K57, Karolinska University Hospital, Huddinge.

Contact person:
Professor Outi Hovatta
Department for Clinical Science, Intervention and Technology (CLINTEC)
Division of Obstetrics and Gynecology, K57
Phone +46 8 585 838 58
Fax:08-585 875 75

Aim:
The purpose of this 5-day course is that the participants learn the principles of clinical research and will be able to plan a clinical research project. It will help basic scientists to interpret the results of clinical studie and understand the problems of clinical research.

Contents:
1.Ethics of clinical studies
2.Principles and statistics in clinical studies
3.Collection and handling of clinical material
4.Interview methodology and project planning
5 Analysis and discussion of clinical projects.

Malaria

Course Number:1610g

Credit Points:1,5

Date:26 nov 2007--30 nov 2007

It is compulsory to attend all the lectures. The practical sessions attendance is not compulsory for students with previous knowledge on the specific skills. It will be possible to compensate absence by completing individual assignments provided by the course organizer.

Course organizer:
Anna Färnert
Department of Medicine Solna
Infectious Disease Unit
Anna.Farnert@ki.se

Course leader:
Andreas Mårtensson, Unit of Infectious Diseases, Department of Medicine, Karolinska University Hospital Huddinge,
Asli Kulane, IHCAR, Karoliska Institutet

Contact person:
Kjerstin Björkholm
Department of Medicine Solna
Infectious Disease Unit
Phone +46 8 5177 18 61
Fax:+46 8 5177 18 06

Aim:
The aim is to provide a broad knowledge about malaria, one of the main causes of morbidity and mortality in tropical low and middle-income countries

Contents:
Malaria epidemiology, life cycle, morphology, pathogenesis, clinical aspects, diagnostic methods. Principles for therapy and prophylaxis, pharmacology and resistance to antimalarial drugs. Immunology, genetics and vaccines. Entomology and vector control. Public health and socio-economic aspects. New control policies and research strategies

Tuberculosis and other bacterial infections

Course Number:1610h

Credit Points:1,5

Date:3 dec 2007--7 dec 2007

It is compulsory to attend all sessions. Abscence will be compensate with individual assignments provided by the course organizer.

Course organizer:
Jan Andersson
Department of Medicine Huddinge
Infectious Disease Unit
jan.andersson@ki.se

Course leader:
Susanna Grundström, Department of Medicin

Contact person:
Berit Lecomte
Department of Medicine Huddinge
Infectious Disease Unit
Phone +46 8 5858 1919
Fax:+46 8 746 62 80

Aim:
The overall aim is to provide knowledge about Tuberculosis morbidity and mortality in low and middle income countries. Special focus is on research methodology used in field studies

Contents:
Tuberculosis: overview on epidemiology, gender aspects, immunology, pathogenesis, diagnostic methods, principles of therapy, prevention and control with special emphasis on the situation in low and middle income countries. Multidrug resistant TB, Molecular mechanisms in drug resistance. Methology for clinical, epidemiological and health system studies in TB International public health aspects on TB. The interaction between HIV and TB.

HIV and other viral infections

Course Number:1610i

Credit Points:1,5

Date:10 dec 2007--14 dec 2007

It is compulsory to attend all sessions. Abscence will be compensate with individual assignments provided by the course organizer.

Course organizer:
Jan Andersson
Department of Medicine Huddinge
Infectious Disease Unit
jan.andersson@ki.se

Course leader:
Jan Andersson, Department of Medicin

Contact person:
Berit Lecomte
Department of Medicine Huddinge
Infectious Disease Unit
Phone +46 8 5858 1919
Fax:+46 8 746 62 80

Aim:
The overall aim is to provide knowledge about HIV related infectious diseases that are important causes of morbidity and mortality in low and middle income countries. Special focus is on research methodology and clinical treatment effects used in field studies.

Contents:
HIV/AIDS: overview on epidemiology, transmission and gender aspects with focus on the situation in low and middle-income countries, immunology and pathogenesis, clinical aspects, diagnostic methods, therapeutic principles and monitoring of efficacy/development of resistance. Methods for monitoring of viral resistance. Viral genotyping. Methodology for clinical, epidemiological and health systems studies in HIV/AIDS. Global access to anti-retroviral drugs. Community-based approaches to HIV treatment in low-income countries

Clinical and experimental neuroimmunolgy

Course Number:1627

Credit Points:1,5

Date:5 nov 2007--9 nov 2007

All lectures, demonstrations and group tasks are compulsory. Compensation for absence can be discussed with the course directors.

Course organizer:
Maja Jagodic
Dept. of clinical neuroscience
Division of Clinical CNS Research
Maja.jagodic@ki.se

Course leader:
Erik Wallström

Contact person:
Erik Wallström
Dept. of clinical neuroscience
Division of Clinical CNS Research
Phone -46 8 51776241
Fax:+46 8 5177 62 48

Aim:
The aim of this course is to increase the understanding of neuroinflammatory diseases both from a clinical and experimental perspective, to enable a more focused and clinically relevant future research in the neuroinflammatory field.

Contents:
The course includes clinical overviews of symptoms, signs, pathology, treatments and diagnostic criteria for the most important neuroimmunological diseases; MS, MG, GBS/CIDP, some rheumatic diseases. Also included is an overview of experimental models of neuroimmunological diseases, with an emphasis on techniques for genetic analysis (intercrosses, congenics etc.). Key molecules in neuroinflammation will also be covered; MHC-TCR, costimulation, chemoattractants. Some techniques will also be discussed; DNA vaccination, advanced imagning, high-throughput genotyping and expression analysis. The relation between neurodegeneration and inflammation will be analyzed.
The course combines traditional lectures (usually in the morning) with one demonstration at the animal dept., a group assignment/seminar and an interactive presentation / discussion the last day. IT will be required to solve the group assignment. The group assignment will consist of collecting data on a specific topic (IL-17 in neuroinflammation, Ncf-1, CTLA-4) and presenting structured and interpreted key data for the whole student group and the course leaders the last day of the course

DNA-Proteins interactions in vivo: Gene regulation, factor binding and chromatin remodeling

Course Number:1642

Credit Points:1,5

Date:3 dec 2007--7 dec 2007

Lectures and practical excercises are obligatory. Absence from the practicals is compensated according to the instructors of the course leader.

Course organizer:
Sergey Belikov
Cell and Molecular Biology

sergey,belikov@ki.se

Course leader:
Örjan Wrange och Carolina Åstrand

Contact person:
Inger Westin Jonsson
Cell and Molecular Biology
Molecular Cell Biology
Phone 08-524 87371
Fax:+46 8 31 35 29

Aim:
DNA replication, gene expression, and chromatin structure and almost all other processes taking place in the cell nucleus, are regulated by proteins that bind specific DNA sequences. Although the DNA-binding specificities of many of these proteins have been characterized in vitro. It is essential to understand how they function in the context of the living cell. This course will provide an overview of many of the techniques being used to identify DNA-protein interactions in vivo and in situ.

Contents:
Lectures and lab practice.

From stress to disease: an integrated view

Course Number:1658

Credit Points:1,5

Date:22 oct 2007--26 oct 2007

If absence from any daily summary a written summery of the essentials is required.

Course organizer:
Rosario Leopardi
Department of Clinical Neuroscience

rosleo@ki.se

Course leader:
Rosario Leopardi

Contact person:
Lisbeth Eriksson
Dept Clinical Neuroscience

Phone +46 8 51775018
Fax:+46 8 319105

Aim:
The goal of this course is to provide a comprehensive overview on stress, a basic phenomenon present in all forms all life. The course is planned as a multidisciplinary approach to a biomedical problem. Teachers from the basic, the clinical and the social sciences will integrate their expertise to convey a translational view.

Contents:
The course will cover: (i) the physiopathological mechanisms of stress, with emphasis on the basic cellular and molecular biology as well as on complex, multi-organic integrated responses; (ii) experimental research models of stress; (iii) stress-induced human pathology in the clinical setting; (iv) social and psychological aspects. The course us a five-day, full-time (8:30 am - 4:30 pm) course composed of lectures (no laboratory or practical parts). Every day will end with a summery.

Health Policy and Management

Course Number:1659

Credit Points:7,5

Date:8 oct 2007--9 nov 2007

Group work, project work including presentation and discussions. Absence from some group work will lead to compulsary written report of the respective theme. Participation in project presentation and individual discussion is a prerequisite for passing the examination and getting the credit points.

Course organizer:
Professor Göran Tomson
Department of Public Health and Department of Learning, Informatics, Management and Ethics
Division of International Health (IHCAR) and Medical Management Centre (MMC)
goran.tomson@ki.se

Course leader:
Mats Brommels, MMC
Pia Maria Jonsson, MMC
Clas Rehnberg, MMC
Cecilia Stålsby Lundborg, IHCAR
Rolf Wahlström, IHCAR
John Øvretveit, MMC

Contact person:
Catherine Boman
the Department of Learning, Informatics, Management and Ethics
Medical Management Centre
Phone +46 8 524 836 64
Fax:+46 8 524 836 00

Aim:
The aims of the course are to review scientific approaches to the formulation of health policies and the management of health systems as well as to support participants in the development of a research proposal.

Contents:
A mix of lectures, exercises and group work will introduce health management and leadership; health economics; health technology assessment; health policy analysis and systems comparison; and health service utilisation. An important part is individual HPM project work. Depending on participants background ranging from a literature review to drafting manuscripts, literature review or manuscript.

Ischemic heart disease: from bedside to experimental models

Course Number:1669

Credit Points:1,5

Date:3 dec 2007--7 dec 2007

Group seminars and demonstrations

Course organizer:
John Pernow
Department of Medicine K2
Division of Cardiology
john.pernow@ki.se

Course leader:
Anders Gabrielsen, Department of Medicine K2

Contact person:
Anders Gabrielsen
Department of Medicine
Center of Molecular Medicine
Phone 08/51776424
Fax:+46 8 313147

Aim:
To provide an integrated insight into the pathophysiology and clinical manifestations of ischemic heart disease by combining theoretical and clinical background, demonstrations of experimental models for investigating the disease, clinical demonstrations, and treatment strategies. This will help the students design proper mechanistic, experimental and clinical studies testing a hypothesis based on a clinical problem.

Contents:
Lectures will cover the pathophysiology of ischemic heart disease including mechanisms behind atherosclerosis and thrombosis, endothelial function, ischaemia/reperfusion injury and genetic and epidemiologic aspects of ischemic heart disease. Imaging techniques in the diagnosis of ischemic heart disease are described in lectures. In addition, clinical lectures covering symptoms, treatment regimens and their limitations, and some possible future modes of treatment. Lectures will be held by basic scientists and clinical researchers.
Demonstration of experimental models of ischemic heart disease ranging from in vivo models in large and small anaesthetised animals to isolated heart preparations.
Demonstrations of techniques used in clinical research such as vascular and cardiac ultrasound, flow measurements, magnetic resonance imaging and coronary imaging.
Group seminars in which the students will define a clinical problem and design a proper study to resolve it.
This course is now considered as part (fourth course) of a block of 4 courses specially planned to give the PhD students in the area of Cardiovascular Research a continuous and non-overlapping education on the mechanisms of function of the vascular wall and its consequences to health and disease. Attendance to the whole block is advised and in this case the courses should preferably be attended in the order 1554-1551-1710-1669. For those who prefer, participation in single courses is also acceptable.

The Global Diabetes Epidemic

Course Number:1678

Credit Points:3

Date:22 oct 2007--26 oct 2007

Some lectures and the oral presentation are compulsory.

Course organizer:
Claes-Göran Östenson
Department of Molecular Medicine and Surgery
Rolf Lufts Centrum för Diabetesforskning
claes.ostensson@karolinska.se

Course leader:
Claes-Göran Östenson, Inst of Molecular Medicine, Endocrine and Diabetes Unit, Karolinska University Hospital, Solna

Contact person:
Eva Toft
Department of Medicine, Huddinge (MedH)
Diabetesmottagnignen, MTC, Ersta sjukhus
Phone +46 8 714 62 45
Fax:+46 8 566 346 08

Aim:
The aim is to give a broad overview of diabetes mellitus, especially of type 2 diabetes. The course is intended for graduate students and postdoctoral fellows.

Contents:
The main objective of this course is to offer an overview diabetes mellitus, with special focus on type 2 diabetes mellitus. This one-week course will be composed of interactive seminars and lectures. The course content will include: Diagnosis of diabetes: new recommendations by the WHO, implications for prevalence of disease and cost of treatment; Epidemiology, global aspects, diabetes in developing countries and industrialised countries; Pathogenesis/aetiology of both type 2 and type 1 diabetes; Primary and secondary prevention of type 2 diabetes; Late diabetic complications: prevalence, prevention and treatment; Therapy of diabetes, including novel treatment principles; Health economy of diabetes. The course will end with an oral presentation of a project by the participants.

Epidemiology III: Analysis and interpretation of data

Course Number:1684

Credit Points:1,5

Date:26 nov 2007--30 nov 2007

Course organizer:
Lars Alfredsson
Institute of Environmental Medicine
Cardiovascular epidemiology
lars.alfredsson@ki.se

Course leader:
Anders Ahlbom, Lars Alfredsson, Institute of Environmental Medicine, Dept of Epidemiology

Contact person:
Anita Berglund
Institute of Environmental Medicine
Cardiovascular epidemiology
Phone +46 8 524 874 66
Fax:+46 8 31 39 61

Aim:
The aim of the course is to give an advanced understanding of the theory and practice of epidemiological research. The course is of interest for Ph.D.-students in epidemiology.

Contents:
The course will cover the following topics: causal inference, interaction, analysis of dose-response, the role of statistics in epidemiology, and strategies for analyzing epidemiological data in theory and practice. The course includes lectures as well as exercises and group discussions on selected topics.

The course is mandatory in the Ph.D.-program in epidemiology. In order to get accepted to the course it is required that the students have passed an introduction course in epidemiology and biostatistics (Epidemiology I, Epidemiology II and Biostatistics I, or corresponding courses). It is also strongly recommended that students have passed an intermediate course in biostatistics, such as Biostatistics II, or corresponding courses.
Please provide the following important information in your application under "Reason for applying for this course": institution, supervisor, state when you passed the following obligatory courses (or provide details of corresponding courses), preferred course language (Swedish or English)
OBS! Demands for this course: Bio I, Epi I and Epi II

Biostatistics III: Survival analysis for epidemiologists

Course Number:1685

Credit Points:1,5

Date:7 nov 2007--13 nov 2007

Course organizer:
Paul Dickman
Medical Epidemiology and Biostatistics

Paul.dickman@ki.se

Course leader:
Tomasz Burzykowsky

Contact person:
Marie Dokken
Medical Epidemiology and Biostatistics

Phone +46 8 524 823 41
Fax:+46 8 31 49 75

Aim:
The course aims to introduce statistical concepts and methods for
Analyzing time-to-event data with emphasis on applications in epidemiology and public health.

Contents:
This course introduces statistical methods for survival analysis with emphasis on the application of such methods to the analysis of epidemiological cohort studies. Topics covered include methods for estimating patient survival (life table and Kaplan-Meier methods), comparing survival between patient subgroups (log-rank test), and modelling survival (primarily Poisson regression and the Cox proportional hazards model). The course addresses the concept of time as a potential confounder or effect modifier and approaches to defining time (e.g., time since entry, attained age, calendar time). The course will emphasise the basic concepts of statistical modelling in epidemiology, such as controlling for confounding and assessing effect modification.

How to Write and Publish a Scientific Paper in English (*)

Course Number:1686

Credit Points:1,5

Date:4 sep 2007--2 oct 2007

5 consecutive Tuesday afternoons 3-5 pm at Karolinska University Hospital Huddinge. Failure to attend any session will have to be compensated by extra homework.

Course organizer:
Pehr Lind, Assoc Prof KI
Institutionen Medicin HS (H7)
KI Huddinge
pehr.lind@karolinska.se

Course leader:
Pehr Lind, Associate Professor at KI

Contact person:
Birgitte Kahl-Lindholm
Inst Medicin HS (H7)
KI Huddinge
Phone +46 8 616 4303
Fax:+46 8 616 44 86

Aim:
This is an introductory course in scientific writing and publishing for PhD-students. The student will aquire the skills to write a complete and correct scientific manuscript in English and to handle the publication process successfully. He/she will also master the basics of scientific English. The participitants will, furthermore, at the end of the course be able to analyze and critize scientific texts with respect to format and content.

Contents:
Five interactive teaching sessions (5 X 2h), review of a scientific paper (four homework (4 X 2h), written examination: composition of an abstract and a title for a scientific text (6h). Work in group concerning analysis and criticism of a scientific text (4h).
The following parts are addressed in this course: What is scientific writing? What is an original article? How to select a good title? How do I compose the title page? How to list the authors? How do I write the abstract/ the introduction/ the material & methods/ the results and discussion sections? Rules for citations and references? How to design effective tables, graphs, photos? How to submit my manuscript/ the cover letter? How to avoid rejection? How to deal with a rejection letter. The referee system and publishing process. Ethics and etiquette in scientific writing. Common mistakes in writing scientific English/ avoiding jargon.
The course is concluded with a multiple choice test covering essential issues on scientific writing. The students will, furthermore, have the opportunity to submit examples of their ongoing manuscripts for review and constructive criticism.

Data collection and data analysis II (*)

Course Number:1711

Credit Points:7,5

Date:4 sep 2007--4 dec 2007

Taking part in all seminars is compulsory. Absence from seminar is to be compensated by a two page long written critical discussion of a theme realted to seminar content. Absence from final seminar is to be compensated by writing a 5 page long discussion of two other students written papers to final seminar.

Course organizer:
Mats Granlund
Neurobiology, Care Sciences and Society and Mälardalen University
ISB
mats.granlund@hhj.hj.se

Course leader:
Mats Granlund, Institutionen för samhälls- och beteendevetenskap, Mälardalens högskola i samverkan med Karolinska Institutet

Contact person:
Sofi Almers
School of Health Sciences
Jönköping University
Phone +46 36 101193
Fax:+46 21 10 13 90

Aim:
The aim of the course is to support students in developing in depth knowledge about a reserch method they use in their own dissertation work

Contents:
Content is focusing on supporting students in gaining an in-depth understanding of a research method that they use in their own dissertation work and to provide an introduction in methods for systematic literature reviews.

Research strategies and design problems in caring sciences

Course Number:1734

Credit Points:7,5

Date:1 oct 2007--15 jan 2008

Viewing lectures at time of convenience every week as well as participating in scheduled video seminars every week is compulsory. Absence from activities is to be compensated by writing a 2 page long discussion of the video seminar from which the student was absent..>

Course organizer:
Mats Granlund
Neurobiology, Care Sciences and Society and Jönköping University
School of Health Sciences
mats.granlund@hhj.hj.se

Course leader:
Mats Granlund,
Institutionen för samhälls- och beteendevetenskap, Mälardalens högskola

Contact person:
Sofi Almers
School of Health Sciences
Jönköping University
Phone +46 36 101193
Fax:+46 21 10 13 90

Aim:
To support students in developing in depth knowledge about validty and reliability in designing quantitative and qualitative studies

Contents:
The content is focusing on presenting and discussing different research designs in quantitative and qualitative research traditions (e.g randomized control trials, single subject designs, grounded theory, discourse analysis) in relation to principles and criteria for drawing valid conclusions. Principles that will be discussed in quantitative designs include internal validity, construct validity, statistical validity and external validity and in qualitative studies questions of quality and verification

The ubiquitin-proteasome system in health and disease

Course Number:1738

Credit Points:3

Date:3 sep 2007--14 sep 2007

Group work and seminars are compulsory.

Course organizer:
Maria Masucci
CMB

maria.masucci@ki.se

Course leader:
Nico Dantuma, CMB

Contact person:
Yvonne Strandberg
CMB

Phone +46 8 524 86279
Fax:+46 8 33 13 99

Aim:
This is an advanced course intended for research students with projects or an interest in the ubiquitin system involved in pathogenesis particularly relevant for basic and clinical research students focused on cancer, degenerating diseases or infections.

Ubiquitin-mediated regulated proteolysis of intracellular proteins plays a crucial role in many basic cellular processes, including cell cycle regulation, transcriptional activation, and quality control. The growing interest in the system and in proteolysis as a novel regulatory mode and a crucial player in the pathogenesis of a broad variety of diseases, has attracted numerous researchers to the field. Many laboratories in the Karolinska Institute and affiliated hospitals in Stockholm, Sweden, and across Europe are studying different aspects of the system.

This course will review the story of the ubiquitin system as we currently know it. From the regulation of basic cellular processes, through quality control and the pathogenetic mechanisms of disease, from X-ray crystallography of the 26S proteasome, to the interaction between substrates and their ligases, to the development of mechanism-based drugs to target specific pathologic processes.

The course will directed by Dr. Aaron Ciechanover, Dr. Maria Masucci and Dr. Nico Dantuma and will include plenary lectures from experts in the field as well as presentations of selected topics/articles by the participants. The course will include the historical background of the system, the current state of knowledge of the components of the system and their mode of action, key examples for involvement of the system in regulating basic cellular processes, the involvement of the system in pathogenesis of diseases, and the prospects for development of mechanism-based drugs to target some of the diseases.

Contents:
This is a full-time daily 2-weeks course containing lectures (20 hrs), group work (18 hrs) individual work (2 hrs) and seminars (10 hrs).

Cytostatic Drugs in Research and Cancer Treatment

Course Number:1741

Credit Points:1,5

Date:12 nov 2007--16 nov 2007

In case of absence, the student has to acquire appropriate knowledge from the recommended literature, may get the consultation with the course leader (if needed) and write short report.

Course organizer:
Zuzana Hassan
Dept. of Laboratory Medicine, KI
KFC Novum
Zuzana.Hassan@ki.se

Course leader:
Moustapha Hassan, Professor, Dept of Medicine Huddinge, KI
Mats Remberger, PhD, Dept of Laboratory Medicine, KI

Contact person:
Zuzana Hassan
Dept. of Laboratory Medicine, KI
KFC Novum
Phone +46-8-58583856
Fax:+46 8 58583810

Aim:
To convey an outline of knowledge about cytostatic drugs and their role in research and cancer treatment.

Contents:
Classification of cytostatics
Mechanism of action of cytostatics
Interactions between cytostatics and other drugs
Aspects concerning pharmacokinetics, pharmacodynamics and pharmacogenetics of cytostatics
Treatment strategies using cytostatics
Mechanisms of apoptosis
Mechanisms underlying drug resistance
Safety regulations and routines according to the Swedish Legislation

Developmental Biology

Course Number:1744

Credit Points:6

Date:10 dec 2007--29 feb 2008

Course organizer:
Agneta Nordenskjöld
Dept of Molecular Medicine and Surgery
Genetics
agneta.nordenskjold@ki.se

Course leader:
Per Kylsten
Developmental Biology
Department for Natural Sciences
Södertörns högskola
mailto:per.kylsten@sh.se

Magnus Nord
Div of Respiratory Medicine, Dept of Medicine
Karolinska Institute
Karolinska University Hospital - Solna
mailto:magnus.nord@mednut.ki.se

Agneta Nordenskjöld
Dept of Molecular Medicine, CMM
Karolinska Institute
Karolinska University Hospital - Solna
mailto:agneta.nordenskjold@cmm.ki.se

Contact person:
Agneta Nordenskjöld
Dept of Molecular Medicine and Surgery
Genetics
Phone +46-8-517 764 08 alt. +46-8-517 777 05
Fax:+46 8 517 736 20

Aim:
To give students an understanding of basic concepts within developmental biology, including pattern formation mechanisms and clinical aspects of developmental biology, and also to introduce students to cutting edge research within developmental biology.

Contents:
Current advances in stem cell research have revealed a greater need for general understanding of the mechanisms that control animal development and pattern formation. Modern developmental biology is an interdisciplinary research field including e.g. cell and molecular biology, cell signalling, embryology, genetics, genomics and proteomics, but has also clinical applications in pediatrics, obstetrics and oncology. Experimental studies are usually concentrated to a small number of animal model systems, e.g. C. elegans, the mouse, drosophila, and zebra fish. This course caters for students who wish to learn about developmental biology, both for those with, and those without, previous contacts with the discipline. The first week serves as a thorough introduction to developmental concepts and basic mechanisms covered by fulltime lectures and literature studies. A leading edge research seminar series on developmental topics will follow. Every week an invited lecturer will present a current facet of developmental biology research, in the form of one review lecture followed by a full research seminar. During these following weeks, pattern formation mechanisms, evolution-developmental biology (evo-devo) and clinical aspects are covered. Course assessment will be based upon completion of weekly literature assignments reflecting the research seminars and course literature. A preliminary schedule including a list of invited speakers is available at http://decs.ki.se (under the heading Postgraduate Course Program).

Social Innovation and Entrepreneurship

Course Number:1766

Credit Points:5

Date:25 oct 2007--11 dec 2007

This course is scheduled to run over two periods in half-tempo. Schedule can be found on www.sses.se

Course organizer:
Professor Mats Brommels
LIME
SDO
mats.brommels@mmc.ki.se

Course leader:
Michael Schragger SSES

Contact person:
Rasmus Rahm
Stockholm School of Entrepreneurship
Course Co-ordination
Phone +46 8 736 15 91
Fax:+46 8 736 15 91

Aim:
The aim of this course is to introduce students to the context of social innovation and social entrepreneurship. Through project work students will increase their understanding of various theories and practices from the field, while being exposed to the action-oriented skills required for developing and implementing a social innovation and/or creating the social-oriented new venture.

Contents:
Content
In our society social needs are addressed in a variety of different ways. Some of these needs are addressed mainly through public organisations, some in private spheres through associations or businesses, and others in informal organisations or maybe not at all. As changes occur in our society, the current practices we use to meet our needs will not necessarily be the same practices we use to meet our needs in the future. In response, a number of initiatives are emerging. The creation of these new initiatives is the focus of this course.

Social innovation involves the identification of new problems and finding new solutions for action, individually or collectively. Entrepreneurship, as the process of developing and carrying out these initiatives, focuses on creating new ‘worlds’ in our minds, in how we discuss these with others, and finally how we actually carry out concrete activities.

Social innovation and entrepreneurship can, and probably will, involve logics from different sectors of society. During the course, ethical, moral and normative issues will be considered in relation to practical examples and project work.
Course topics include:

·Placing innovation & entrepreneurship in a social context
·Entrepreneurship and practices of different sectors
·Innovation and creativity
·Organizing and mobilizing people
·Financing and risks
·Indicators for success and accountability
·Surviving and growing, or?
Structure
A three-hour session held once each week for the entire autumn term.

The course will start with an introduction of theories in the field and different practical examples. During the second phase students will work on projects and action-oriented skills will be elaborated on in seminars. Through these projects students will be able to identify their area of interest
Teaching methods
A blend of teaching methods including lectures, guest lectures, case analysis and presentations and group discussions will be used for the course. Furthermore, there will be monologues, dialogues as well as debates with some of the leading players from academia, business, government and society.
Prerequisites
Students must have a minimum of 80 university credits (120 ECTS respectively), especially in the areas of technology, economics, medicine or biomedicine. Experience with administration/management from a practical or theoretical perspective may be valuable, but is not required.
Assessment
Examination will be conducted through final project work/presentations and class/group contributions. Since this is an emerging field, class discussions will be of great importance. Therefore attendance is required and recommended.

Although there will be no formal exam, students will be required to satisfactorily complete all of the course assignments in order to receive a passing grade.
Literature
Course Compendium incl. selected readings and articles.
Other
Responsible institutions
The Stockholm School of Entrepreneurship, Karolinska Institute

www.sses.se

Studiedesign vid klinisk forskning

Course Number:1794

Credit Points:4

Date:14 sep 2007--26 oct 2007

För godkänd kurs krävs deltagande vid samtliga seminarietillfällen (fredagar v 37-43) samt aktivt deltagande i grupparbete och hemuppgifter liksom läsning av kurslitteraturen.

Course organizer:
Catarina Jansson
Institutionen för molekylär medicin och kirurgi
Enheten för esofagus- och ventrikelforskning (ESOGAR)
Catarina.Jansson@ki.se

Course leader:
Jesper Lagergren, Catarina Jansson och Mats Lindblad

Contact person:
Margrete Gellervik
Institutionen för molekylär medicin och kirurgi
Enheten för esofagus- och ventrikelforskning (ESOGAR)
Phone + 46 8 517 709 57
Fax:46 8 331587

Aim:
Kursen har som mål att ge kursdeltagaren grundläggande kunskap om hur olika typer av kliniska/epidemiologiska studier designas samt att öka förståelsen för metodologiska aspekter som kan påverka en vetenskaplig forskningsstudie.

Contents:
Kursen omfattar 7 veckors kursarbete inkluderande föreläsningar samt examination i form av projektarbete och artikelgranskning (2.5 veckors heltidsstudier). Fredagar v 37-43 kl 14.00-16.15 ges vid 7 tillfällen seminarier. Följande innehåll presenteras: 1) Grundläggande begrepp, 2) Mått på sjukdomsförekomst och mått på samband/effekt, 3) Livskvalitet i klinisk forskning, 4) Experimentella studier; randomiserade kliniska prövningar och sensitivitet/specificitet, 5) Observationella studier; kohortstudier/fall-kontrollstudier, 6) Systematiska/slumpmässiga fel och kausalitet, 7) Muntlig examination och kursutvärdering. En stor del av kursen ägnas åt ett omfattande projektarbete ”Att designa sin egen studie”. Ytterligare en hemuppgift innebär granskning av vetenskapliga artiklar. Obligatorisk kurslitteratur är boken ”Epidemiology -an introduction” av Kenneth J Rothman år 2002. Läsning av boken (ca 200 sidor) är obligatorisk. Kursen riktar sig till forskarstuderande med intresse för klinisk forskning i allmänhet och till kliniskt verksamma forskarstuderande i synnerhet. Det är en fördel att gå kursen tidigt under forskarutbildningen.

The Methods for Qualitative Content Analysis

Course Number:1814

Credit Points:4,5

Date:26 sep 2007--8 nov 2007

The course in its whole needs active involvement of the students through participation in the various types of teaching

Course organizer:
Ella Danielson
Departments of Neurobiology, Care Sciences and Society and Health Sciences, Mid Sweden University

Ella.danielson@miun.se

Course leader:
Professor Gerd Ahlström, Örebro Universitet
Docent Ella Danielson, Mitthögskolan

Contact person:
Marianne Svedlund
Department of Health Sciences, Mid Sweden University

Phone 46 63 165654
Fax:

Aim:
The aim of the course is for the student to deepen his/her knowledge of qualitative content analysis to the extent that he/she is able to understand the origin of the method, to use the method in qualitative studies as well as to describe and critically evaluate it.

Contents:
The course includes lectures about the development of content analysis, design, elements of the analysis. The students will with support from lectures, individual literature assignments apply content analysis in their own research and reflect on the application in a critical way.

From genome to global malaria: diversity and control

Course Number:1823

Credit Points:1,5

Date:26 nov 2007--30 nov 2007

Course organizer:
Akira Kaneko
Department of Medicine, Solna
Infectious Disease Unit
akira.kaneko@ki.se


Contact person:
Kjerstin Björkholm
Department of Medicine, Solna
Infectious Disease Unit
Phone +46 8 517 718 61
Fax:

Aim:
The UN Millennium Goals have adopted malaria as a top priority. A major problem is however area-specific diversity, which affects disease and intervention. The completion of the genome sequences of Homo sapiens, Plasmodium falciparum, and Anopheles gambiae heralds a new era. We apply the new insights to the on-going research in isolated areas. Islands provide natural experiments. The expansion of parasites is coinciding with humans. Tracing the routes from mainland Africa to islands, we aim at a better understanding of how humans, parasites and mosquitoes have co-evolved over time and resulted in the diversity. Our ultimate goal is to develop a novel area-specific strategy in the malaria challenge of the 21st century.

Contents:
1. Diversities of the biological agents in malaria transmission:
a) human (immunity/ drug metabolism),
b) parasite (antigenicity/ drug resistance) &
c) vector (refractoriness/ insecticide resistance)
with neutral markers,
2. Evolutionary and ecological processes to promote diversities:
a) historical human settlement patterns,
b) natural environments; climate, island size, fauna and flora,
c) socio-cultural environments; inter- and intra-island human movements, language, and community, and
d) modernization and development; agriculture, local health system, malaria chemotherapy, use of bed nets, and poverty.
e) co-evolutionary processes of biological agents through extension of transmission dynamics & population genetics;
3. Implications of biodiversities on immunities and interventions against malaria infection and disease, toward improved control strategies in relation to local characteristics.

This 2007 course shares the same aims with the previous courses: 2004/2005 Molecular epidemiology with a special focus on malaria (course number 1823) , and 2006 Global malaria in the post-genomic era (course number 18231).
Students with different disciplines are encouraged to participate in this course: including clinical science, molecular medicine, epidemiology, ecology, environmental medicine and public health. Interactions among them will be an important component of the course.

Ideation Creating a Business Idea

Course Number:1838

Credit Points:7,5

Date:5 sep 2007--17 oct 2007

Schedule can be found on www.sses.se

Course organizer:
Professor Alf Rehn
KTH
Indek
alf@kth.se


Contact person:
Rasmus Rahm
Stockholm School of Entrepreneurship
Course Co-ordination
Phone +46 8 736 15 91
Fax:+46 8 736 15 91

Aim:

The aim of this course is to give students knowledge about the process of creating and developing a business opportunity. The course stretches all the way from the pre-idea to the creation of the business idea through to the identification of market demand and competitive analyses and finally to the issues surrounding the actual launching of the product or service. Using real world examples and analysis emphasis is placed on the creative process surrounding the development of a sound business idea, the identification of a distinct target market and the development of a strong business model.

Contents:

Thinking up an interesting business idea is not the end of the process, in fact, it is just the beginning. This idea must be developed into a business concept and a true business opportunity through market and competitive analysis. This subject demands innovative and entrepreneurial work and requires creativity and problem solving skills.

The course will further encompass:
-Creativity
-Finding and/or creating business ideas
-Identifying the target market
-The business model
-Opportunity selection
During the course the students will be challenged to identify areas of need, to find and create business ideas, and to develop business concepts and opportunities.
Structure
There will be two weekly sessions lasting two, respectively three hours each for seven weeks. Final project hand-in and presentations will take place during the eighth week.

Students with the best business ideas will be given the chance to present them to a panel of entrepreneurs and venture capitalists.
Prerequisites
Students must have a minimum of 80 university credits (120 ECTS respectively), especially in the areas of technology, economics, medicine, biomedicine or design. Experience with administration/management from a practical or theoretical perspective may be valuable, but is not required.
Assessment

-Written assignments
-Final individual project

Although there will be no formal exam, students will have to satisfactorily complete all the requirements throughout the course in order to receive a passing grade.
Literature
Course Compendium incl. selected readings and articles.
Other
Responsible institutions
The Stockholm School of Entrepreneurship, The Royal Institute of Technology

Planning - Developing a Venture

Course Number:1839

Credit Points:7,5

Date:31 oct 2007--12 dec 2007

Schedule can be found on www.sses.se

Course organizer:
Professor Alf Rehn
KTH
Indek
alf@kth.se


Contact person:
Rasmus Rahm
Stockholm School of Entrepreneurship
Course Co-ordination
Phone +46 8 736 15 91
Fax:+46 8 736 15 91

Aim:
The main objective is to lead the participating students through a business development process, involving everything from the development of the idea to the final business plan. The underlying objectives are:
-Development of ideas
-Sorting of ideas
-Creation of a business plan for new ventures or established businesses
-Evaluation of the business plan and to decide whether a business can be established, taking into account marketing, economic and organisational issues

Contents:

As the commercialisation of an idea into a business is highly dependent on the will power and competence of the people involved, the team must be highly motivated and have a real trust in their project as well as the competence to develop the idea into a business.

The ideas developed within the framework of the course should be innovative in the sense that they are based on technical innovations, new scientific results, or new creative methods for organising resources or marketing products and services. Start by looking in your own backyard; a lot of interesting research and development is going on at The Royal Institute of Technology, The Stockholm School of Economic, The University College of Arts Crafts and Design and Karolinska Institute.

People with real life experience gained from entrepreneurial work and business development will give some of the scheduled lectures during the course.
Students shall form groups by four to develop their ideas into business plans. Ideas and plans will be discussed at seminars attended by co-students and a ‘coach’. The objective of the seminars is to provide students with a forum to discuss their ideas with other students who study different disciplines and who bring to the seminar a variety of skills and business ideas. Toward the end of the seminar series the main objective changes to producing a business plan and to discussing the possibility of successfully launching the different business ideas.

The two best business plans presented during the course will have the opportunity to participate in the competitions -European Business Plan of the Year- organised by London Business School and INSEAD and -Venture Challenge- organised by San Diego State University. Both events are frequented by Venture Capital businesses that are interested in supporting promising young entrepreneurs. Previous participants at this event from the SSES are today managing successful enterprises.
Structure
There will be two weekly sessions lasting two hours each for seven weeks. In addition to this business plan teams will meet several times to be coached in smaller groups by an expert. Each session will involve a mix of teaching methods, see below. Presentation to a panel of the completed business plan will take place in an additional week.
Teaching methods
The course will involve lectures and regular seminars with academics as well as practitioners. Subsequently, each student team will be mentored throughout the actual creation of the business plan by an individually assigned coach.
Prerequisites
Students must have a minimum of 80 university credits (120 ECTS respectively), especially in the areas of technology, economics, medicine, biomedicine or design. Experience with administration/management from a practical or theoretical perspective may be valuable, but is not required.
Assessment
The course is structured around the creation of an actionable business plan and students will be assessed on their course participation and individual theoretic assignment, their completed business plan and the presentation of their plan to a judging panel.

Although there will be no formal exam, students will be required to satisfactorily complete all of the course assignments in order to receive a passing grade. Attendance is required and recommended.
Literature
Course Compendium incl. selected readings and articles
Other
Responsible institutions
The Stockholm School of Entrepreneurship, The Royal Institute of Technology

www.sses.se

Business Opportunities in ICT

Course Number:1840

Credit Points:5

Date:30 aug 2007--16 oct 2007

Schedule can be found on www.sses.se

Course organizer:
Professor Lena Ramfeldt
KTH
IMIT
lena@ramfelt.com


Contact person:
Rasmus Rahm
Stockholm School of Entrepreneurship
Course Co-ordination
Phone +46 8 736 15 91
Fax:+46 8 736 15 91

Aim:

This course gives an understanding of the context and the environment for companies within the Information Communication Technology (ICT) sphere. This is a course for anyone who sees their future in ICT: as an entrepreneur, an engineer, a venture capitalist, a policy-maker, or as a scholar. We will critical examine different aspects of ICT to understand different preconditions for the ICT-sphere.

Contents:
Content
During the course we will discuss conditions that affect companies operating within ICT, such as globalization, privatization, de-regulations, different types of milieu that host ICT-clusters. We will map out different players and their places in different value-chains, and we will cover cutting edge technology within ICT as well as security and open source approaches in the development of the technology. We will bring in guests from different fields related to ICT who bring a variety of perspectives of what has happened, what is going on right now, and what will be the future for ICT-enterprises.
Structure
There will be two weekly sessions lasting two hours each for seven weeks. Each session will involve a mix of teaching methods, see below. This will be supplemented by seminars and breakout groups.
Teaching methods
A blend of teaching methods including lectures, guest lectures, case analysis and presentations, and group discussions will be used for the course. Furthermore, there will be monologues, dialogues as well as debates with some of the leading players from academia, business, government, and society.
Prerequisites
Students must have a minimum of 80 university credits (120 ECTS respectively), especially in the areas of technology, economics, medicine or biomedicine. Experience with administration/management from a practical or theoretical perspective may be valuable, but is not required.
Assessment
·Oral assignments
·Group projects presented both as a report and orally
·Attendance at seminars
Literature
Castells, M & Pekka Himanen The Information Society and the Welfare State: The Finnish Model Oxford University Press: 2002
Himanen, P. The Hacker Ethic and the Spirit of the Information Age. New York: Random House 2001
Rosenberg, D Cloning Silicon Valley, the next generation high-tech hotspots Reuters 2002
Rice, J Tensions and Dynamics in Standards Based Networks in Periods of Industry Contraction: Lessons from the Bluetooth Consortium
Other
Responsible institutions
The Stockholm School of Entrepreneurship, The Royal Institute of Technology

www.sses.se

Methodologies in Molecular Medicine

Course Number:1844

Credit Points:3

Date:27 sep 2007--6 dec 2007

Course organizer:
Docent Harvest F. Gu


harvest.gu@ki.se

Course leader:
Harvest F. Gu Department of Molecular Medicine

Contact person:
Docent Harvest F. Gu
Molecular Medicine and Surgery KS

Phone 08-51779515
Fax:+46 8 51773658

Aim:
The aims of this course are to introduce fundamental knowledge and general protocols of the major methods used in molecular medicine and to provide participants with examples of how to adopt advanced methods in their own research.

Contents:
Lectures will mainly concern the methods as below:
PCR, RT-PCR and In situ-PCR
DNA sequencing analysis
SNP genotyping
Analysis of single cells
Padlock probes
Southern, Northern and Western blotting
FISH and PRINS
CGH array
SiRNA
HPLC
Transgenic and Knock-out animals

Basic course in International Health, focussing on field survey method

Course Number:1845

Credit Points:10,5

Date:20 aug 2007--28 sep 2007

It is compulsory to attend all the lectures. Absence will be compensate by extra individual assignments provided by the course organizer. (7 weeks course, first 2 weeks Online [20- 31 August]; following 5 weeks [3 Sept- 5 Oct] at Karolinska Institutet)

Course organizer:
Asli Kulane
Department of Public Health Sciences
International Heath (IHCAR)
asli.kulane@ki.se

Course leader:
Anna Mia Ekström,
Bo Eriksson,
Hans Rosling,
Vinod Diwan,
Karin Källander
Department of Public Health Sciences
Division of International Health (IHCAR)

Contact person:
Gunilla Risberg
Department of Public Health Sciences
International Heath (IHCAR)
Phone +46 8 5248 3349
Fax:

Aim:
The aim is to provide an overview of the global health situation and how it is measured. To review the principles for epidemiological survey methods used for health research in low and middle-income countries, focusing on the underlying concepts of the epidemiological approach and study design.

Contents:
Philosophy of science, observation/experiments; free/commissioned dimensions of research from cell to society. Basic to applied and evaluation of research, policy and practice. Sociology of research on gender, ethnicity and poverty.

Principles for assessment of health development. The usefulness and limitations of different health indicators; availability and quality of health and development data. Methods for burden of disease measurements; analysis of health determinants; use of international data sources for assessment of the impact of globalization on health.

Basic knowledge of different health systems and their financing. Role of different elements and actors in the health system and organization and management of health systems in low-income countries. Principles for assessment of health systems performance as well as the impact of gender on health system measurement. Cost-effectiveness and feasibility of interventions in widely varying socio-economic contexts.

The methodologies used for sample survey in different contexts, including survey design, sampling techniques, management of data, descriptive data analysis and presentation. Research method appropriate for measurement of different exposures and outcome in epidemiological or studies, where there is no register, are given special emphasis, including standardized data collection procedures, quality control, assessment of validity and reliability. Skills in using IT-tools in surveys and in collection, transport and storage of biological specimens.

Improving drug use, especially antibiotics

Course Number:1846

Credit Points:1,5

Date:12 nov 2007--16 nov 2007

It is compulsory to attend all the lectures. Absence will be compensate by extra individual assignment provided by the course organizer.

Course organizer:
Cecilia Stålsby Lundborg
Department of Public Health Sciences
International Heath (IHCAR)
Cecilia.Stalsby.Lundborg@ki.se

Course leader:
Rolf Wahlström, IHCAR
Otto Cars, STRAMA, SMI
Cecilia Stålsby Lundborg

Contact person:
Gunilla Risberg
Department of Public Health Sciences
International Heath (IHCAR)
Phone +46 8 5248 3349
Fax:

Aim:
The overall aim is to give a view of the role of medicinal drug use, especially antibiotics, in societies throughout the world, focussing on interventions to improve drug use.

Contents:
Sources to describe drug utilisation will be presented, together with possibilities and difficulties to collect appropriate data to show the level of drug use in a given population. Methods to estimate the level of self-medication and people’s beliefs and behaviour will also be shown and discussed. The use of antibiotics will be used as an example as infections are one of the leading causes of morbidity worldwide. Furthermore, the use of antibiotics carries a special problem in that resistance affecting not only previously treated persons but also previously untreated persons may spread throughout the world. Antimicrobial resistance has been recognized as a threat to public health in all countries, by both WHO and EU. Examples of antibiotic use from from countries of different income level and from different parts of the health system will be presented and discussed. In addition factors affecting drug use, both on macro- and micro-level will be mapped out and discussed. The case of Europe will be presented, where it has been shown that antibiotic use is very different between neighbouring countries which indicates that other factors beside strict medical factors play an important role. Decisions to use drugs are taken in homes, pharmacies or other drug outlets, within primary health care as well as in hospitals. The concept of rational use of drugs includes correct use of good quality drugs at an affordable cost. Methods to increase the rational use of drugs, and in particular antibiotics, will be presented, including the role of guidelines and various kinds of information or educational interventions directed to health care professionals, patients or the public. Ways of evaluating such interventions will be presented and discussed. The concept and content of National Drug Policies (NDP), which include elements such as legislation and drug quality assurance, development of guidelines and information material, and monitoring of drug use, will be presented. The development and implementation of an NDP in Laos - a low income country - will be used as an example. One specific feature of the Lao NDP is that health systems research has been included as one element, and several projects concerning antibiotic use have been carried out.

Quality of life as an outcome measure in care sciences

Course Number:1873

Credit Points:3

Date:14 nov 2007--7 dec 2007

The examination consists of a review of a research proposal. The task will be introduced during the first part of the course. Absence from group-seminars will be made up with a essay-writing on the topics that were to be discussed in the group-seminar.

Course organizer:
Lena Wettergren
Department of Neurobiology, Care sciences and Society
Division of Nursing
lena.wettergren@ki.se

Course leader:
Regina Wredling, leg. sjuksköterska, professor, institutionen för omvårdnad, KI
Lena Wettergren, leg. sjuksköterska, Med dr, institutionen för omvårdnad, KI
Mirjam Sprangers, PhD, for adj professor, institutionen för omvårdnad, KI

Contact person:
Agneta Wennman-Larsen
Department of Neurobiology, Care Sciences and Society
Division of Nursing
Phone +46 8 524 836 77
Fax:

Aim:
The aim of the course is to broaden and deepen the knowledge concerning measurement of quality of life in care sciences. The concept quality of life and health-related quality of life will be discussed in the context of care science. The course will further include phrasing research questions, choosing appropriate instruments, designing quality of life studies (timing of assessments and procedure), choice of methods for analysis, and interpretation of results.

Contents:
The course is divided in two parts, the first part consist of three full-time days (14-16 November) and the second part of two full-time days (6-7 December), three weeks later. The course is based on lectures during morning sessions, which will be followed up in group-seminars in the afternoons. Between the two parts of the course students are required to hand in one homework task which will constitute the examination. The concept quality of life and health-related quality of life will be discussed to give insights into these concepts. Aditionally the criticism against these concepts and their measurement will be addressed. The course will further include phrasing research questions, choosing appropirate instruments, designing studies measuring quality of life (timing of assessments and procedure), choice of methods for analysis, and interpretation of results.

International Classification of Functioning, Disability and Health

Course Number:1874

Credit Points:3

Date:1 sep 2007--20 dec 2007

Taking part in all lectures and seminars is compulsory as well as taking part in final exam seminar. Absence from a seminar is to be compensated by a two page long written critical discussion of an application of ICF in the students own research area. Absence from final seminar is to be compensated by writing a 5 page long discussion of the other students written papers to final seminar.

Course organizer:
Lena von Koch
Department of Neurobiology, Care sciences and Society
Division of Occupational Therapy
Lena.von.Koch@ki.se

Course leader:
Prof. Eva Björck-Åkesson. PhD., Mälardalens Högskola
Prof. Mats Granlund, PhD., Mälardalens Högskola
Prof. Rune Simeonsson, PhD, Mälardalens Högskola

Contact person:
Malin Lindell
Department of Neurobiology, Care Sciences and Society
Division of Occupational Therapy
Phone +46 8 524 838 30
Fax:

Aim:
The aim of the course is to support students in developing in depth knowledge about Inetnational classification od functioning, disability and health, ICF, as a research tool

Contents:
Content is focusing on presenting and discussing the conceptual model of ICF and the philosophy behind the model. In addition applications of the model in research are presented. Applications that will be discussed include linking rules for assigning ICF codes to items from extant instruments, adapting ICF to self-ratings by users and use of ICF in register based research. The course is organized as distance education entailing streamed web-based lectures and seminars.

Physiology and Pharmacology III: Cardiovascular, Pulmonary and Muscle Physiology and Pharmacology

Course Number:1887

Credit Points:3

Date:8 oct 2007--19 oct 2007

Course organizer:
Einar Eriksson
Dept of Physiology and Pharmacology

einar.eriksson@ki.se

Course leader:
Einar Eriksson

Contact person:
Einar Eriksson
Dept of Physiology and Pharmacology, Karolinska Institute

Phone 08/52487200
Fax:468332047

Aim:
This course is part of the basic training for graduate students at the Department of Physiology and Pharmacology. The aim of this course is to provide the students with an insight in the ongoing research at this department. This includes the basic training in cardiovascular, pulmonary and muscle physiology and pharmacology.

Contents:
The course will focus on physiological and pharmacological principles within the cardiovascular, respiratory and muscular systems and their adaptation to various conditions. The content will reflect a broad area from molecular principles of importance for physiology and pharmacology to integrative functions in these organ systems. Furthermore, pathophysiological aspects will be lectured and demonstrated. Each day will be hosted by a research group at the department and will include lectures and practical demonstration in the field. The course will also give a broader knowledge in methods and models used in cardiovascular, pulmonary and muscle research.

Execution Running Your Own Company

Course Number:1896

Credit Points:7,5

Date:3 sep 2007--23 oct 2007

Schedule can be found on www.sses.se

Course organizer:
Associate Professor Mikael Samuelsson
SSE
E-section
Mikael.samuelsson@hhs.se


Contact person:
Rasmus Rahm
Stockholm School of Entrepreneurship
Course Co-ordination
Phone +46 8 736 15 91
Fax:+46 8 736 15 91

Aim:

The objective of the course is to enable the student to run a business of her or his own. The course is designed to address important issues faced when running a company, focusing on critical processes and in particular processes required in the young firm.

Contents:
Content
The course focuses on supporting the student in her or his decisions and other action in the new business venture. It is assumed that students entering the course have a formulated business idea to be realized, as well as a genuine interest in pursuing this business idea in their own company.

The outline of the course is built on experience from active entrepreneurs and follows the typical stages in a new venture, starting with the evaluation and refinement of the existing business idea, moving on to resourcing (venture capital supply, internal resources etc), market and communication plans etc. The course will focus on

-Strategy (What?) i.e. markets, offer, business idea, getting-started and setting up a board of directors
-People (Who?) i.e. entrepreneurial team, recruitment and motivation
-Operational work (Let’s do it!) i.e. management/culture, sales/marketing, production and negotiation.

Theoretically, the course connects to the opportunity-based models of entrepreneurship and business creation, as well as to a contextual approach to the venture creation process (i.e. the idea that the very character of the venture creation process is dependent on the type of business, as for instance in the biotechnology, TIME, finance or environmental technology sectors).

Students with the best business projects will be given the chance to present them to a panel of entrepreneurs and venture capitalists.
Structure
There will be two weekly sessions lasting three hours each for seven weeks. Final project hand-in and presentations will take place during the eighth week.
Teaching methods
A blend of teaching methods including lectures, guest lectures, case analysis and presentations, project work and group discussions will be used for the course.
Prerequisites
Students must have a minimum of 80 university credits (120 ECTS respectively), especially in the areas of technology, economics, medicine, biomedicine or design. Experience with administration/management from a practical or theoretical perspective may be valuable, but is not required.

In order to be admitted to the course, the students must have a formulated business idea to be realized. It is assumed that students entering the course are in the process of establishing a new venture.
Assessment
Cases and projects
-Contribution in class and group activities
-Written report on theoretical aspects of the new venture process.

Although there will be no formal exam, students will be required to satisfactorily complete all of the course assignments in order to receive a passing grade. Attendance is required and recommended.
Literature
Course Compendium incl. selected readings and articles
Other
Responsible institutions
The Stockholm School of Entrepreneurship, The Stockholm School of Economics

www.sses.se

Growth Managing your Firm

Course Number:1899

Credit Points:7,5

Date:29 oct 2007--12 dec 2007

Schedule can be found on www.sses.se

Course organizer:
Associate Professor Mikael Samuelsson
SSE
E-section
Mikael.samuelsson@hhs.se


Contact person:
Rasmus Rahm
Stockholm School of Entrepreneurship
Course Co-ordination
Phone +46 8 736 15 91
Fax:+46 8 736 15 91

Aim:

The objective of this course is to provide students with insights into the problems and opportunities involved in managing growth in entrepreneurial ventures. The course is designed to introduce a series of concepts, frameworks, and heuristics that enable people to manage entrepreneurially in organisations of all sizes and types.

Contents:
Content
The course focuses on the decisions and actions owner-managers take in recognising and choosing opportunities, obtaining and allocating resources, challenging and directing personnel, and adapting personal goals and corporate strategies to changing personal and business conditions. In this process, the course examines management challenges that are typical of different stages in the business’s development start-up, growth, change of direction, etc.

Using this framework, the course will discuss issues of particular importance to rapidly growing firms such as developing networks, managing with limited resources, cash planning, delegation, and professionalizing the business as it grows, dealing with crises, while at the same time being careful to avoid stifling the entrepreneurial spirit as the organisation becomes larger and more complex.
Structure
There will be two weekly sessions lasting three hours each for seven weeks. Final project hand-in and presentations will take place during the eighth week.
Teaching methods
A blend of teaching methods including lectures, guest lectures, case analysis and presentations, and group discussions will be used for the course.
Prerequisites
Students must have a minimum of 80 university credits (120 ECTS respectively), especially in the areas of technology, economics, medicine or biomedicine. Experience with administration/management from a practical or theoretical perspective may be valuable, but is not required.
Assessment

-Individual pre-class case analysis
-In-class participation
-Group field project
-Book review

Attendance is required and recommended.
Literature
Course Compendium incl. selected readings and articles.
Other
Responsible institutions
The Stockholm School of Entrepreneurship, The Stockholm School of Economics
www.sses.se

Proteomics in cancer research

Course Number:1900

Credit Points:1,5

Date:5 nov 2007--9 nov 2007

Course organizer:
Janne Lehtiö
Tumor biology, MTC
MTC
Janne.lehtio@ki.se

Course leader:
Elena Kashuba

Contact person:
Janne Lehtiö
Department of Oncology/pathology
Karolinska Institutet
Phone +46-8-51776391
Fax:468330498

Aim:
The aim of the course is to learn basics of current proteomics methods and how these are applied in cancer research as well as understand the possibilities and limitations of proteomics.

Contents:
Couse will provide understanding in current clinical proteomics methods (2DE, mass spectrometry, TMA, data handling etc.), proteomics research process and current status on cancer proteomic high lighted by case studies.

Astma, allergi och eksem i arbetslivet

Course Number:1921

Credit Points:3

Date:10 dec 2007--13 jan 2008

Kursen har schemalagd tid på KI campus 2007-12-10 till 2007-12-13, och examination 2008-01-11. I mellantiden skrivs ett eget arbete. Obligatoriska moment är närvaro vid demonstrationer i lunglab och hudlab, samt falldiskussioner.

Course organizer:
Anne Renström
Lung- och allergiforskning
Institutet för miljömedicin
Anne.Renstrom@ki.se

Course leader:
Magnus Lindberg, Arbets- och miljömedicin, Yrkes- och miljödermatologi, Norrbacka 171 76 Stockholm

Contact person:
Anne Renström
Lung- och allergiforskning
Institutet för miljömedicin
Phone + 46 8 524 822 08
Fax:+ 46 8 300 619

Aim:
Målet med kursen är att deltagaren ska få ökad kunskap om och ökad kompetens i att undersöka arbetets betydelse för astma, allergi och eksem.

Contents:
Denna övergripande kurs skall ge deltagarna aktuell kunskap om
- allergi, astma och eksem: epidemiologi, mekanismer, diagnostik och behandling
- individuella riskfaktorer
- riskyrken, arbetsmiljörisker och riskbedömning
- yrkesval och allergi
- arbetsmiljölagstiftning och förordningar
- monitorering av arbetsplatsen och mätning av allergener
- prevention och interventionsåtgärder
- forskningsläget angående astma, allergi och eksem i arbetslivet inklusive experimentella studier av mekanismer, och metoder för diagnostik och behandling.
Deltagarna får träning i att analysera fall i samverkan med deltagare med annan bakgrund, samt i att sammanställa en forskningsplan inom forskningsfältet, inkl metoder och etiska överväganden, och att analysera andras arbeten. Kursen ges på svenska.

Global Entrepreneurial Leadership

Course Number:1930

Credit Points:5

Date:10 oct 2007--11 dec 2007

Schedule can be found on www.sses.se

Course organizer:
Professor Lena Ramfelt
KTH
IMIT
lena@ramfelt.com

Course leader:
Consulting professor Tom Kosnik, Stanford University

Contact person:
Rasmus Rahm
Stockholm School of Entrepreneurship
Course Co-ordination
Phone +46 8 736 15 91
Fax:+46 8 736 15 91

Aim:
The purpose of Global Entrepreneurial Leadership is to provide students at the National University of Singapore and SSES, as well as a cadre of Silicon Valley "Young Jedi" Global Entrepreneurial Leaders, with insights about how to lead an entrepreneurial organization and how to create trust across your network of stakeholders and supporters.

Contents:
Content
Through the application of cutting-edge multimedia and distance learning, participants will be exposed to best-of-class lessons from entrepreneurs and thought leaders in Sweden, Singapore, Silicon Valley, and selected other entrepreneurial regions. The SSES and NUS students will compare the lessons of Silicon Valley entrepreneurial leaders with those of entrepreneurs and leaders in their own regions, and develop a personal philosophy and code of conduct for themselves as the next generation of entrepreneurial leaders. Silicon Valley "Young Jedi" will develop their skills as global entrepreneurs, preparing them to more effectively collaborate with entrepreneurs and members of the Circles of Influence in other innovative regions around the world. Members of all three learning groups will develop their professional global networks.

The course will be taught by faculty at Stanford, KTH and NUS, in collaboration with the Stanford Center for Professional Development. Students in Sweden will earn academic credit from their respective SSES member school. Students in Singapore will earn academic credit from the National University of Singapore. All students who successfully complete the course will also receive a certificate of completion from the Stanford Center for Professional Development.
Prerequisites
Students must have a minimum of 80 university credits (120 ECTS respectively), especially in the areas of technology, economics, medicine, biomedicine or design. Experience with administration/management from a practical or theoretical perspective may be valuable, but is not required.

Assessment
The main resources for facilitating the learning are our students, the teaching-team, and all the entrepreneurial leaders that in one way or another will participate during the course. For every session there is one topic to be covered. The topics will be announced prior to the session in order for the participants to collect and share essential information related to the topic. For every session there will either be a group or an individual assignment to be prepared before the session. The participants find their own material for the topic at hand; reading papers and books, doing interviews, watching movies. All sources that are used have to be cited. In addition to the above described examination also includes a project report.
Literature
The course will use documentation and specifications available on the course web.
Other
Responsible institutions
The Stockholm School of Entrepreneurship, The Royal Institute of Technology

www.sses.se

Languages of Innovation and Entrepreneurship

Course Number:1931

Credit Points:7,5

Date:30 aug 2007--16 oct 2007

Schedule can be found on www.sses.se

Course organizer:
Professor Ronald Jones
Konstfack
Institution for Interdisciplinary Studies
Ronald.jones@konstfack.se


Contact person:
Rasmus Rahm
Stockholm School of Entrepreneurship
Course Co-ordination
Phone +46 8 736 15 91
Fax:+46 8 736 15 91

Aim:

The aim of this course is to establish a shared language of innovation by tearing down the traditional walls between the different academic disciplines.

Students will acquire specific creative and management skills that exploit innovation as a cross disciplinary strategy and will thus better understand the interdependency between the disciplines.

Contents:
Content
The course will build partnerships between participants through an understanding as well as an appreciation that the language of innovation and entrepreneurship is universal. In seminars and lectures devoted to a close study of theories of innovation and entrepreneurship, the shared language will be established. The language will be put into play in a “hands on” interdisciplinary case-study.

Working collaboratively, participants will design a break through innovation, real or imagined, and then continue the collaboration by preparing a strategic plan for this new growth enterprise. The plan will include finding and creating new markets for the innovation and managing the development of new markets and new technologies.
The participants will create a final project to be presented publicly. An emphasis will be put on presentation skills.
Structure
The course is divided into two halves:
-The first half of the course contains five weeks of seminars and lectures addressing the theory of innovation and entrepreneurship.
-In the second half of the course, cross disciplinary innovation teams will be created and an interdisciplinary case study will be introduced. Participants will then mock up a strategic plan for this new growth enterprise.
Teaching methods
The course will incorporate lectures, debates, case analysis and exercises by the participants as well as leaders in the field.
Prerequisites
Students must have a minimum of 80 university credits (120 ECTS respectively), especially in the areas of technology, economics, medicine, biomedicine or design. Experience with design from a practical or theoretical perspective may be valuable, but is not required.
Assessment
-In class written and oral assignments
-Contribution in class and group activities
-Final group project
-Presentations

Although there will be no formal exam, participants will be required to satisfactorily complete all of the course examination components in order to receive a passing grade. Attendance is compulsory.

Evaluation will be based on: the conceptualization and design of a innovation with plausibility, creativity, and a high degree of technical resolution, and the ability to create and translate this innovation into a new growth business. The final proposals and presentations should be cross disciplinary.
Literature
Required readings: Course Compendium incl. selected readings and articles.
Other
Responsible institutions
The Stockholm School of Entrepreneurship, The University College of Arts, Crafts and Design

www.sses.se

Neuropsychopharmacology of schizophrenia

Course Number:1935

Credit Points:1,5

Date:12 nov 2007--16 nov 2007

Course organizer:
Kent Jardemark
Physiology and Pharmacology
Pharmacology
Kent.Jardemark@ki.se


Contact person:
Kent Jardemark
Physiology and Pharmacology
Pharmacology
Phone +46 8 52487918
Fax:+46 8 308424

Aim:
The aim of this course is to study pharmacological strategies in the treatment of schizophrenia.

Contents:
Research groups within the Department of Physiology and Pharmacology will arrange different parts of the course, and internationally distinguished researchers will be invited to give lectures in the field of schizophrenia. The course consists of both lectures and demonstrations of techniques and models.

Embryology I

Course Number:1999

Credit Points:1,5

Date:22 oct 2007--26 oct 2007

The laboratory parts are obligatory. Not attendance of the laboratory activity; student should present a literature work related with the subject of the missing activity.

Course organizer:
José Inzunza
Department of Biosciences and Nutrition at Novum and Department of Clinical Science

jose.inzunza@mednut.ki.se

Course leader:
José Inzunza and Julius Hreinsson

Contact person:
Julius Hreinsson
Depatment of Clinical Science
Division of Obstetrics and Gynecology Karolinska University Hospital, Huddinge
Phone +46 (8) 5858 6804
Fax:

Aim:
The aim of the course is to instruct the participants in human reproductive biology with focus on assisted reproduction technologies (ART), as well as to give them practical experience and training in embryological and micromanipulation techniques.

Contents:
Sperm theory
1. Anatomy of the testis, sperm production and maturation, fertilization.
2. Cryopreservation of spermatozoa.
3. Sperm preparation for IVF and ICSI, criteria for ICSI.
Embryology
1. Follicle growth and maturation, ovulation.
2. Cell biology and oocyte genetics.
3. Embryo development in-vitro, morphological evaluation of embryos.
4 Cryopreservation of embryos, theory and practice.
5. Embryonic stem cells.
6. Selection of embryos for transfer and cryopreservation.
Laboratory
1. How to work with sperm, oocytes and embryos.
2. Manipulation and training with mouse oocytes and mouse embryo handling.
3. Micromanipulation techniques, presentation.
4. Micromanipulation training. ICSI and embryo biopsy.
Genetics
1. Genetic aspects of prenatal diagnostics and PGD.
2. Cloning techniques.
Course test, evaluation, discussions and closing of course

Advanced seminars in Tumor Biology IV

Course Number:2000

Credit Points:3

Date:1 sep 2007--21 dec 2007

To attend the seminars and participate in the discussions on these. Written exam end of course,

Course organizer:
Ingemar Ernberg
MTC, C1
Ernbergs group
ingemar.ernberg@ki.se

Course leader:
Galina Selivanova, Eugene Zabarovsky, MTC


Contact person:
Yvonne Strandberg
Dept of Cell and Molecular Biology
Masuccis group
Phone +46 8 5248 6279
Fax:+46 8 330744

Aim:
To learn about the frontiers of cancer research in areas such as apoptosis, cell cycle, genetics, epigeneteics, cell-cell communication, infections & cancer, immunology, signal transduction.

Contents:
Seminars and discussions once a week, usually on Tuesdays at 13.00-14.15; 15 occasions. Oral and written exam end of December,

What is life? The future of biology: IV

Course Number:2001

Credit Points:2,2

Date:1 sep 2007--21 dec 2007

To attend the seminars and participate in the discussions on these. Wriiten exam end of course,

Course organizer:
Ingemar Ernberg
MTC, C1
Ernbergs group
ingemar.ernberg@ki.se

Course leader:
Peter Århem, Neuro, KI; Anders Wennborg, Novum, Huddinge


Contact person:
Yvonne Strandberg
Dept of Cell and Molecular Biology
Masuccis group
Phone +46 8 5248 6279
Fax:+ 46 (8) 33 13 99

Aim:
Inspired by the seminal book by Erwin Schrödinger What is life? published 60 years ago we will address this question again, in view of the impressive development since then.
There are many new concepts to consider in the future of biology, such as the consequencies of the -omics era, complexity, computation and simulation, as well as the role of mathematicss and physics in biological theory. This is the 4th term and will be a continuation on earlier seminars with new topics. The course can be taken as a separate one, or as a continuation of the earlier courses.
Every occasion is planned to consist of a 1-2 hour discussion workshop with the invited guest + a seminar, i.e altogether 3 hrs. Presence will be required on 80% of the occassions. The course is organized together with the KI Kulturrådet.

Contents:
2 seminars+worskhop every month for five months, 2,5-3 hrs on each occassion..
The course will cover areas such as biocomplexity, quantum mechanical theory in biology, computation and simulation (in silico biology), organization of biological systems, causality in biology, how does chemistry become electric and magnetic forces and evolutinary theory in the light of molecular biology.
The invited speakers will also be asked to meet the students for an additional 1-2 hours in a workshop during the afternoon for basic concepts.
Speakers on earlier courses have been: Stuart Kaufmann, Sidney Brenner, Günter Stent, Svante Pääbo, Carleton Gajdusek, Sui Huang, Eörs Szathmary, Günter von Kiedrowski, Lenny Guarente, Stephen Wolfram.

Ekonomiska utvärderingar av medicinska teknologier (Economic evaluations of medical technologies)

Course Number:2003

Credit Points:1,5

Date:5 nov 2007--9 nov 2007

Absence from the course will be compensated with own reading of the missed area and a writted report (about 2 pages)

Course organizer:
Clas Rehnberg
LIME
Medical Management Centre
Clas.Rehnberg@ki.se

Course leader:
Jonas Lundkvist, Medical Management Centre (MMC)
Fredrik Borgström, Medical Management Centre (MMC)
Patrik Sobocki, Medical Management Centre (MMC)


Contact person:
Fredrik Borgström
LIME
Medical Management Centre
Phone +46 8 545 28 543
Fax:+46 8 545 28 549

Aim:
The objective of the course is to give the participants basic knowledge in interpreting and conducting economic evaluations. The course will also stimulate a critical and reflecting relation to the area, and also give an international understanding of the role of health economics in health care decision-making.

Contents:
The course will cover basic concepts and methods of health economic evaluation, which also will be worked on in practical cases. The course contains the following parts:
-Cost-of-illness
-Measurement of clinical effectiveness
-Evaluation methods (cost-minimisation, cost-benefit, cost-effectiveness and cost-utility analysis)
-Modelling
-Statistical methods
-Use and influence of economic evaluation

Datahantering och data analys med SPSS-syntax

Course Number:2009

Credit Points:1,5

Date:13 sep 2007--25 sep 2007

Vid frånvaro från datasalsundervisning/-övning får doktoranden göra kompletterande övningsuppgift/-er.

Course organizer:
Göran Sidebäck
ISB
Mälardalens högskola
goran.sideback@mdh.se

Course leader:
Göran Sidebäck, docent i sociologi

Contact person:
Göran Sidebäck
ISB
Mälardalens högskola
Phone + 46 (0)21 107006
Fax:

Aim:
Kursen syftar till att ge kunskaper om hur man använder olika syntaxkommandon i SPSS för att definiera, beskriva, modifiera, selektera och analysera data, samt kunskaper om hur syntax kan användas för dokumentation, kommunikation och återbruk

Contents:
Kursen omfattar totalt en veckas heltidsstudier, dels i datasal (undervisning och handledda övningar med diskussion) och dels som egna självständiga övningar.
Under kursen behandlas bl.a. kommandon för att definiera, beskriva, modifiera, selektera och analysera data. Kursen inleds med en övergripande genomgång av hur syntax kan genereras, sparas och användas och hur grundläggande variabelkommandon kan utföras med syntax, vilket exemplifieras genom demonstrationer på för alla tillgängliga data. Genom strukturerade uppgifter får doktoranden pröva olika tekniker. Kursen fortsätter med att deltagarna själva arbetar med olika övningsuppgifter under handledning, bl.a. sker en fördjupning i syntaxmetodik med inriktning på urvals- och selektionsprocedurer. Avslutningsvis diskuteras olika arbetssätt för att dokumentera datakontroller, datamodifikationer, nybildning av variabler med syntax (för att möjliggöra återbruk och dokumentation).
Data från bl.a. Levnadsnivåundersökningen (Institutet för Social Forskning) används i kursens demonstrationer och övningsuppgifter.

Konsekvenser av modellval och antaganden vid kvantitativ datanalys

Course Number:2010

Credit Points:3

Date:11 sep 2007--27 sep 2007

Aktivt deltagande i ett seminarium.

Course organizer:
Göran Sidebäck
ISB
Mälardalens högskola
goran.sideback@mdh.se

Course leader:
Per-Anders Lindén, docent i sociologi, Stockholms Universitet
Göran Sidebäck, docent i sociologi, Mälardalens Högskola

Contact person:
Göran Sidebäck
ISB
Mälardalens högskola
Phone + 46 (0)21 107006
Fax:

Aim:
Kursen syftar till att ge kunskaper om hur modellantaganden, variabelval, mått, mättidpunkter (tvärsnittsstudier eller longitudinella/panelstudier) och hur urval av enheter vid en regressionsanalys påverkar analysens resultat och slutsatser.

Contents:
Kursen omfattar två veckor heltidsstudier. Undervisningen utgörs av lektioner, seminarier och egna praktiska tillämpningar/övningar. Kursen börjar med en genomgång/diskussion av regressionsanalysens antagande/förutsättningar och konsekvenser avbrott mot dessa. Därefter redovisas och demonstreras olika regressionsdiagnostiska metoder. Deltagarna får därefter som en övningsuppgift göra olika former av regressionsdiagnostik/residualanalys på ett utdelat datamaterial. Övningsuppgiften redovisas och diskuteras vid det andra undervisningstillfället. Vid detta tillfälle demonstreras också vad som händer vid olika brott mot ansatsens/analysens/modellens antaganden/förutsättningar och hur bl.a. olika slumpurval, variabelkodningar, indexbildningar och mättidpunkter (tvärsnittsstudier eller longitudinella/panelstudier) påverkar estimat och slutsatser. (Deltagarna har även en möjlighet att själva göra olika former av regressionsdiagnostik på sina egna data/regressionsanalyser och att diskutera resultatet.) Deltagarna får sedan skriftligt (och individuellt) bedöma och granska resultatet av en regressionsanalys med hjälp av genomförd regressionsdiagnostik/ residualanalys. Kursen avslutas med ett (obligatoriskt) seminarium där två vetenskapliga artiklar diskuteras och granskas med tyngdpunkt på ansatsens och analysens antaganden/förutsättningar och slutsatsernas giltighet.

Basal immunologi för kliniska forskare

Course Number:2022

Credit Points:3

Date:2 oct 2007--15 nov 2007

Course organizer:
Jan Wahlström
Institutionen för medicin
Enheten för lungmedicin
jan.wahlstrom@ki.se


Contact person:
Therese Östberg
Institutionen för kvinnors och barns hälsa

Phone *46 8 517 756 21
Fax:+46 8 5177 3080

Aim:
Kursen syftar till att ge förståelse för basala immunologiska mekanismer och hur dessa samverkar i kroppens försvar mot olika typer av infektioner, samt kunskap om immunpatogenesen vid olika sjukdomar där immunförsvarets funktion spelar en avgörande roll.

Contents:
Kursen är indelad i två block. Block 1 behandlar grundläggande immunologiska mekanismer inom immunförsvarets två huvuddelar: det konstitutiva (medfödda) och det adaptiva (förvärvade). Block 2 omfattar tillämpningarna av dessa principer i olika kliniska sammanhang, såsom infektionsförsvar, autoimmunitet, allergi och transplantationer samt terapeutisk manipulation av immunförsvaret.



Block 1: (ti-to 2-4 oktober)
Introduktion
Konstitutivt immunförsvar
T-celler
Antigenpresenterande celler
B-celler och antikroppar
Konstitutivt och adaptivt immunsvar mot infektioner
Metoder för att studera immunförsvarets funktion.




Block 2: (ti-to 13-15 november)
Tillämpad infektionsimmunologi
Immundefekter
Autoimmuna sjukdomar
Allergi
Terapeutisk manipulation av immunförsvaret
Transplantation
Tumörimmunologi
Frågor och diskussion
Redovisning av projektarbete.

Experimental laboratory animal genetics

Course Number:2023

Credit Points:1,5

Date:1 oct 2007--5 oct 2007

All moments are compulsory. Absence may be accepted if motivated. Missed lectures may be replaced by home work.

Course organizer:
Catharina Lavebratt
Dept for molekylärmedicin och kirurgi

catharina.lavebratt@ki.se

Course leader:
Catharina Lavebratt, Department of Molecular Medicine and Surgery

Contact person:
Catharina Lavebratt
Dept for molekylärmedicin och kirurgi

Phone 08-5177 6524
Fax:+46 8 517 739 09

Aim:
First, to provide students with an introduction to different animal models used for genetic analysis in medical research today. Second, to provide guidelines for performing breeding studies to minimize the number of animals required as well as providing more reliable and reproducible research results.

Contents:
This lecture and seminar course focuses on an up-to-date presentation of genetic questions in experimental animal research, and the importance of using animal models to understand the molecular mechansisms behind human diseases. Particular emphasis will be on the mouse but other examples of different model systems such as rat, frog, zebra fish and fruit flies will also be discussed. Important aspects when designing molecular genetic studies using mice and rats for mapping monogenetic and complex traits are discussed. Oral presentations of individual project plans using applications of the course content on own on-going or planned research project are part of the examination.

Problem based overview of medical statistics (*)

Course Number:2026

Credit Points:1,5

Date:19 nov 2007--23 nov 2007

Course organizer:
Imre Janszky, MD PhD
Department of Public Health Sciences
Preventive Medicine
imre.janszky@ki.se

Course leader:
Rickard Ljung, MD MPH, Department of Public Health Sciences, Karolinska Institutet

Contact person:
Imre Janszky


Phone
Fax:+46 8 737 38 66

Aim:
The course is designed for health professional with no, or not satisfactory knowledge in statistics. The course has two main aims:
1. to provide help in understanding statistics in medical literature
2. improve the health professional-statistician interaction

The course does not aim at teaching the participants how to perform statistical analyses!

Contents:
Medical professional may not perform statistical analyses themselves but rely on the professional help of statisticians. Nevertheless, even in this case clinicians are supposed to know the possibilities and understand the analyses in order to communicate fruitfully with the statistician and to be able to interpret and critically evaluate the medical literature. The course will provide help to improve the understanding of the statistical methods frequently used in medicine.
The lecturers at this course are mainly medical doctors with statistical knowledge, who are able to talk with medical professionals in their “own language”.

Explanation of some basic terms in statistics and epidemiology (random and systematic error, power, types of variables, distributions, multiply comparisons, p value, hypothesis testing and confidence intervals, measures of risk, types of studies etc.)
- most frequently used uni- and multivariate methods according to the type of studies and type of the variables
- confounding, mediation, independence
- interaction, effect measure modification
- continuous vs. categorical approaches


The course will contain lectures and exercises; the latter ones typically will be based on example papers (including examples for typical pitfalls).

Injury Surveillance and Coding

Course Number:2034

Credit Points:7,5

Date:1 oct 2007--31 mar 2008

Course organizer:
Leif Svanström
Dep of Public Health Sciences
Dep of Social Medicine
leif.svanstrom@ki.se


Contact person:
Lars-Gunnar Hörte
Dep of Public Health Sciences
Div of Social Medicine
Phone + 46 8 737 3781
Fax:+46 8 33 46 93

Aim:
The Goal of the Course is:
To develop the knowledge on methods related to Injury Surveillance and Survey of Injuries as well as how the information can be coded. All this in order to be able to compare data from different regions, Countries or disciplines.

Contents:
Course Schedule
The Course will be given only on Internet using the platform Pingpong with
a rate (speed) of 25%.
The examination is to write a paper with plan for a fictive or real based Injury surveillance system or a survey, with a discussion of the problems to take into account.
e.g. how to code the data.

Course parts

A: Basic about Injury surveillance system
B: Basic about Injury Survey.
C.: ICD 10 revision Basics
D Coding of injuries according to Chapter XX ICD-10
E Coding of injuries according to Chapter XIX ICD-10
F Coding of injuries using ICECI /NCECI
G Injury Severity Coding
H Examination ( Writing a paper)

Introduction to Stata for epidemiologists (*)

Course Number:2041

Credit Points:1,5

Date:1 oct 2007--5 oct 2007

None.

Course organizer:
Rino Bellocco
Medical Epidemiology and Biostatistics

rino.bellocco@ki.se

Course leader:
Rino Bellocco, Department of Medical Epidemiology and Biostatistics
Nicola Orsini, Institute of Environmental Medicine

Contact person:
Camilla Ahlqvist
Medical Epidemiology and Biostatistics

Phone +46 8 524 838 69
Fax:+46 8 31 49 75

Aim:
The aim of the course is to provide a basic knowledge of Stata, a statistical software program, for the analysis of epidemiological data.

Contents:
The course is presented in two parts. The first part assumes no knowledge of epidemiology and biostatistics and introduces the Stata package and basic commands for data manipulation and presentation. The second part focuses on how Stata can be used to effectively manage and analyse epidemiological data. Therefore, basic knowledge of study design and measures of exposure-disease associations is required.
Part 1: (3 days)
The course is designed to gently introduce students to the basics in Stata. It will focus on the minimum number of commands that users should know in order to enter, manipulate, and present data. Specific topics include data-reporting, data-management, formatting and graphics.
Part 2: (2 days)
This part introduces students to basic commands useful in epidemiology. Specific topics include tables and regression models for epidemiologist (cumulative-incidence, case-control and incidence rate data), assessment of confounding and interaction, and common graphical representations.

Pathology (#)

Course Number:2044

Credit Points:3

Date:8 oct 2007--19 oct 2007

All demonstrations are compulsory. Absence must be compensated with a written report about the subject of the demonstration.

Course organizer:
Anna-Klara Rundlöf
Department of Laboratory Medicine
Div of Pathology
anna-klara.rundlof@ki.se


Contact person:
Anna-Klara Rundlöf
Department of Laboratory Medicine
Div of Pathology
Phone +46 8 58582926
Fax:

Aim:
Provide knowledge in important mechanisms of disease processes with special emphasis on cell and tissue injury and malignancy

Contents:
This is a full time course with lectures, seminars and demonstrations, divided into two parts. The first part illustrates cell injury, adaptation and inflammation. Mechanisms of oxidative stress, cellular defense and ageing will be discussed as well as new methods in cellular and molecular pathology. During the second part of the course will focus on tumor development and malignancy. We will discuss how basic pathological reponses to inflammation or injury might be the first steps on a multi-step path to malignancy.

Innovation and technology management

Course Number:2059

Credit Points:4,5

Date:1 oct 2007--19 oct 2007

Participation at the lectures is compulsory. Absence can be approved by the course direction if a hand-in of the topic in question is written based on the course literature and discussions with fellow students and reseachers.

Course organizer:
Carl Johan Sundberg
LIME
Unit for Bioentrepreneurship (UBE)
carl.j.sundberg@ki.se

Course leader:
Alf Rehn, Carl Johan Sundberg (KI, LIME, UBE)

Contact person:
Claudia Hakanen
Stockholm School of Entrepreneurship

Phone +46 8 736 1587
Fax:+46 8 736 15 90

Aim:
To get an understanding of the innovation and commercialization context and the skills to apply this understanding to the participant’s field of research.

Contents:
- Innovation strategy and development, national and regional innovation systems
- Innovation development vis-à-vis research (commercialization, conflicts of interest)
- Identification of ideas, innovation processes, selection criteria, collaborations, licensing and start-ups
- The innovation plan as a tool
- Intellectual Property Rights and Patenting
- Rights and agreements (contracts, ownership issues, handling the teacher’s exception)
- Research within larger consortia
- Innovation Management (developing innovations, finance, collaboration, roles)
- Conceptualizing, packaging and presentation of science-based results
This course is introductory to the course “Innovation in practice”, in which doctoral students will have the opportunity to actively develop and proceed with their own research idea.

The course will be run in collaboration with course 2117, Commercialising Science – Innovation and Entrepreneurship Theory.

Innovation in practice - Medical technology

Course Number:2060

Credit Points:3

Date:5 nov 2007--30 nov 2007

Participation at the lectures is compulsory. Absence can be approved by the course direction if a hand-in of the topic in question is written based on the course literature and discussions with fellow students and reseachers.

Course organizer:
Carl Johan Sundberg
LIME
Unit for Bioentrepreneurship (UBE)
carl.j.sundberg@ki.se

Course leader:
Alf Rehn, Carl Johan Sundberg (LIME, UBE)

Contact person:
Claudia Hakanen
Stockholm School of Entrepreneurship

Phone +46 8 736 1587
Fax:+46 8 736 15 90

Aim:
Provide the participant with a concrete understanding of the benefits of commercialization and a practical basic know-how on how to develop ideas, what to consider and how to proceed with a research-based idea.

Contents:
- Developing innovations (value chain; need and market analysis, different markets, time dependency, risk analysis, business concepts and models, innovation models for different branches and industries)
- Development and exploitation strategies for innovation projects (company forms and their functionality, licensing as instrument and as commercial method, development companies)
- Project coordination and budgeting
- Finance and valuation
- Sales, negotiation, agreements in business relations, marketing of a ‘product’ and project/company
- Conceptualization, packaging and presentation of ‘technical results’
- Business plan, function and use.

Introduktion i neuropsykologi från ett tvärdisciplinärt perspektiv

Course Number:2066

Credit Points:3

Date:1 oct 2007--31 jan 2008

Seminarier, gruppövningar och examination i gruppform är obligatoriska. Ersättningsuppgift diskuteras med kursledningen.

Course organizer:
Aniko Bartfai
Institutionen för klinisk vetenskap, Danderyds sjukhus
Enheten för rehabiliteringsmedicin
Aniko.bartfai@ds.se


Contact person:
Inga Lill Boman
Institutionen för klinisk vetenskap, Danderyds sjukhus
Enheten för rehabiliteringsmedicin
Phone +46 8 655 5393
Fax:

Aim:
Kursen är avsedd för forskarstuderande med annan grundexamen än i psykologi med målsättning att ge en introduktion i neuropsykologisk teori och kunskaper kring val av neuropsykologisk metodik och kännedom om vanliga bedömningsmetoder.

Contents:
Föreläsningar, seminarier, gruppövningar, testdemonstrationer, eget arbete, Kursen ges på deltid, under sammanlagt 6 studiedagar (2 heldagar i taget) med 4-6 veckors uppehåll mellan kursdagarna. Upplägget ger möjlighet för forskarstuderande från andra studieorter att delta. Före och mellan undervisningsomgången förutsätts studenten att använda motsvarande 1 heltidsvecka (sammanlagt 4 veckor) för inläsning och förberedelse av eget arbete. Föreläsningarna följs upp av fråge- och diskussionsstunder, som studenterna förebereder parvis eller i smågrupper. Laborationen i neuroanatomi syftar till ett interaktivt inlärningssätt, där föreläsningen kombineras med uppgifter som ska lösas vid datorn interaktivt i smågrupper. Syftet med gruppövningarna är att ge studenterna möjlighet att reflektera kring neuropsykologiska teorier och metoder och deras relevans för studenternas egen forskning. Vid testdemonstrationer får studenterna tillfälle att praktiskt bekanta sig med materialet och en testsituation. Kunskapskontroll sker genom: granskningsuppgift, där syftet är att tillämpa nyförvärvade kunskaper inom testteori, metodik och sätta det i ett teoretiskt sammanhang; resp. hemskrivning som kunskapskontroll och möjlighet till integration och reflektion inom neuropsykologisk teori.

Statistical analysis of questionnaires by Item Response Theory(*)

Course Number:2077

Credit Points:3

Date:29 oct 2007--16 nov 2007

Course organizer:
Ulf Brodin
Karolinska Institutet/ LIME
LIME/ MEdStat
ulf.brodin@ki.se


Contact person:
Margareta Krook Brandt
Karolinska Institutet/ Lime
Lime/ MedStat
Phone +46 8 52487118
Fax:

Aim:
Att ge deltagarna grundläggande kunskap i IRT-metoder som är speciellt utvecklade för evaluering av enkätdata, där bakomliggande latenta variabler såsom attityder/förmåga skall analyseras.

Contents:
Enkätstudier avser oftast att studera tillstånd/effekter vilka ej direkt kan mätas t.ex. social förmåga, daglig fysisk aktivitet, depression, aggresion etc. Formulär med ett antal graderade frågor (alt. VAS) är en vanlig metod att registrera dessa bakomliggande (latenta) faktorer.
Frågorna formuleras i ordnade klasser såsom:
- mycket sämre, något sämre ingen förändring, något bättre,mycket bättre.
- kan ej, kan endast med viss svårighet, kan utan svårighet.
- nej, tveksamt, ja, ....... etc. ,
vilka ej utan vidare kan jämföras med vad vi vanligen uppfattar som riktiga mätdata med en klart definierad numerisk representation. I de flesta fall kan avstånd och lägen i dessa skalor ej tilldelas något absolut mått utan endast rangordnas.
Metoder byggda på ’Item Resonse Theory’ ( IRT ) introduceras, där den s.k. Rasch-modellen utgör grunden. Detta angreppssätt skiljer sig väsentligt från det vi är vana vid enligt CTT, Clasical Test Theory.
Kursmoment:
Definition och identifikation av latenta variabler och dess skalor.
Konstruktion och test av frågor. Hur skall en enkät konstrueras?
Vad innebär en ordnad kategoriskala?
Definition av IRT- begrepp. Introduktion av den basala Rasch-modellen
Skattning av parametrar och individernas värde på den latenta variabeln.
Passar modfellen data?
Identifikation av onödiga eller missvisande frågor samt överflödiga skalsteg.
Introduktion av generella logistiska IRT modeller och datorprogram för IRT- analys.
Deltagarna skall arbeta med praktiskt genomförda enkätstudier, helst egna om sådana finnes. Koppling till SAS och generella icke linjära modeler kommer också att beröras.
Förkunskaper: 2p i medicinsk statistik vid Karolinska Institutet eller motsvarande.

Qualitative interviews in hearing speech and language research

Course Number:2080

Credit Points:3,75

Date:1 oct 2007--1 nov 2007

Interview training is a process which requires testing ’in vivo’, improvements, reflection between training, the course covers a 5-week period. The course will be offered part-time, either mornings (9-12 a.m.) or afternoons (1-4 p.m.), on average 8 hours per week including lectures seminars and training sessions. The education will be compulsory scheduled all through the course. If the student is unable to be present he/she has to consult the course leader/examinator for adequate opportunities and special assignments to recover missed hours.

Course organizer:
Gunnel Backenroth-Ohsako
Department of Clinical Neuroscience
Division of Psychiatry
Gunnel.Backenroth-Ohsako@ki.se


Contact person:
Britta Weckström
Department of Clinical Neoroscience
Division of Psychiatry
Phone +46 8585 866 23
Fax:

Aim:
To give the students an orientation in qualitative interviews. To increase the awareness of the researcher´s role as an instrument in data collection. To practise interview techniques.

Contents:
the researcher´s role as an instrument in data collection
different perspectives and knowledge for conducting qualitative interviews
intersubjectivity, biases and ethical considerations of interviewing
how to plan an interview guide
how to formulate questions
specific interview techniques
the role of empathy in communication

Statistical modelling using R (*)

Course Number:2081

Credit Points:7,5

Date:11 oct 2007--14 dec 2007

There will be two compulsory sessions with presentations during the course.

Course organizer:
Daniel Olsson
Institutionen för Lärande, Informatik, Management och Etik (LIME)
Medical Statistics
Daniel.Olsson@ki.se


Contact person:
Margareta Krook-Brandt
Institutionen för Lärande, Informatik, Management och Etik (LIME)
Medical Statistics
Phone +46 8 524 871 18
Fax:

Aim:
The course aim is to give a comprehensive treatment of the core of modern statistical modelling.

Contents:
Data analysis cannot be learned without actually doing it. In this course the participants will spend most of their time analysing data. This implies using statistical software, in this course we will use R throughout the course. R is free software available on all platforms including Windows, Macintosh, Linux and UNIX platforms, meaning that participants can download R to their own computer, which will be absolutely necessary for this course. Because R is free, the participants will always have access to the latest version. R requires some effort to learn so the participant should be prepared for some hard work. Since R is the standard for statistical computing among research statisticians participants will always have access to a software which implements modern statistical methods.

However this is not primarily a course about R, even though the participants will certainly learn a thing or two about R. This is primarily a course on statistical modelling. In this course a general framework of statistical modelling will be presented. This framework constitutes the core knowledge for conducting data analysis and includes most of the commonly used statistical methods in medical research as special cases. The course will start with linear models, which includes regression analysis and ANOVA. The course then goes on to study three important extensions to the linear model: Generalized linear models which can represent categorical, binary and other response types. Mixed effects models which can represent data that arise from repeated mesures, longitutinal data or multilevel data. Nonparametric regression models which are very flexible and can be used when there is not a linear relationship between the explanatory variables and the response variable.
Throughout the course the participant will perform a very large amount of practical work. This is the only true way that one can really learn the art of statistical modelling. For each session the participants will be given an exercise that will show that they have understood the concepts of that particular session. Participants will also be given the opportunity to work with their own data and they will give two presentations during the course.

The course will be spread out over a period of 10 weeks. Sessions will be scheduled once a week. Each of these days will start with a lecture in the morning. In the afternoon there will be a practical session in front of the computer. For each session the participants will be given an exercise to be performed using R to demonstrate that they have understood the concepts of that particular session. This exercise should be finished at home and written reports handed in.

Prior participation in the basic course in medical statistics or equivalent is a minimum requirement. The course presumes a good understanding of the basics of statistical inference and elementary calculus.

Posttranslational modification of proteins

Course Number:2090

Credit Points:1,5

Date:15 oct 2007--19 oct 2007

It is compulsory to be present at the seminars, to write an essay and give a short oral presentation based on the essay.

Course organizer:
Helena Andersson
Department of biosciences and nutrition
KI syd
Helena.Andersson@biosci.ki.se


Contact person:
Helena Andersson
Department of biosciences and nutrition
KI syd
Phone +46 8 608 91 20
Fax:

Aim:
The aim of the course is to give an introduction to the most common and well studied posttranslational modifications of proteins and to create an awareness of the complexity and diversity of posttranslational modifications of proteins.

Contents:
The course will give an introduction to some of the most common posttranslational modifications of proteins including phosphorylation, glycosylation, ubiquitination and acetylation. Particular proteins subject to extensive modifications of various sorts will be highlighted. Methods of prediction and analysis of posttranslational modification of proteins will be covered.

Natural Killer Cells: Immunology, Genetics and Diseases

Course Number:2091

Credit Points:1,5

Date:19 nov 2007--23 nov 2007

Laboratory practicals and journal clubs are obligatory. Absence from the practicals is compensated according to the instructors of the course leader.

Course organizer:
Chengyun Zheng
Molecular Medicine and Surgery (CMM)

chengyun.zheng@ki.se


Contact person:
Inger Westin Jonsson
Department of Cell and Molecular Biology
Molecular Cell Biology
Phone 08-524 873 71
Fax:

Aim:

The course provides insight into up-to-date knowledge in natural killer (NK) cell immunology, basic medical genetics, genetic control of NK cell activity and overviews of current progress in etiology, diagnosis and clinical management of the genetic NK cell cytolytic activity deficiency associated diseases.
This course is suitable for both preclinical and clinical PhD students with an interest in immunology, medical genetics and hematological diseases as well as cancers. This course bridges from immunologists and geneticists to clinicians, covering key concepts in translational research from the laboratory to the clinic.

This course will be conducted in English.

Contents:
This five day full-time course consists of lectures on NK cell immunology (12 hours), on medical genetics (6 h), and on the etiology, diagnosis and treatment of the diseases (6 h), journal clubs (2 h), lab work (8 h) and an individual written examination in the form of a project ( 4 h). The course runs at daytime.

Understanding developmental aspects of gastrointestinal malignancies

Course Number:2093

Credit Points:1,5

Date:9 nov 2007--19 nov 2007

All seminars and tutorials are compulsory; extra reading material will be provided on missed subjects. Written assessment of a tentative project application and oral presentation of application based on course content will be required of the students.

Course organizer:
Velmurugesan Arulampalam
MTC
-
velmurugesan.arulampalam@ki.se


Contact person:
Gediminas Greicius
MTC

Phone +46 8 52486670
Fax:

Aim:
To disseminate current knowledge, paradoxes and paradigms in developmental aspects governing gastrointestinal cancers.

Contents:
Genetics and epigenetics; Epidemiology of GI cancers; Inflammation and Cancer; Cancer stem cells and role of immune cells; Disruption of signaling pathways; IBD and CRC; Nutrition and cancer; Microbes and gut homeostasis in cancer development; Advances in current diagnosis and treatments; Drug discovery.

Receptor-mediated toxicity

Course Number:2094

Credit Points:1,5

Date:22 oct 2007--26 oct 2007

Group work and workshops are compulsory. Absence can be compensated by written assignments.

Course organizer:
Johanna Zilliacus
Department of Biosciences and Nutrition

johanna.zilliacus@mednut.ki.se


Contact person:
Johanna Zilliacus
Department of Biosciences and Nutrition

Phone +46 8 58583737
Fax:

Aim:
The aim of the course is to provide state-of-the-art knowledge of toxicological mechanisms mediated by hormone receptors and endocrine signalling pathways.

Contents:
The course will include the following topics: Molecular mechanisms of hormone receptor signalling, Signalling pathways targeted by endocrine disrupting chemicals, Emerging techniques to identify and screen for endocrine disrupters and Mode-of-action implications in risk assessment. The course consists of lectures, group work, methods workshops and student presentations.

How to write a successful grant application (*)

Course Number:2095

Credit Points:3

Date:29 oct 2007--10 nov 2007

The lectures, assignments and group work on reviewing applications are obligatory. Absence can be compensated by writing another application and /or by reviewing other applications within 2 weeks after that the course is finished.

Course organizer:
Professor Olle Söder
Dept. of Woman and Child Health
Pediatric Endocrinology Unit
Olle.Soder@ki.se


Contact person:
Mattias Larsson
Dept. of Public Health
IHCAR
Phone
Fax:

Aim:
The aim of the course is to learn how to write a successful grant application

Contents:
The course will take place at Hanoi Medical University (KIs partner university in Hanoi, Vietnam) and will contain lectures about the various aspects of finding funding opportunities and how to write a grant application, an assignment for each participant to work on her/his own application, group work on the reviewing process exchanging applications between the different groups formed by the course participants, a final review meeting to decide on funding.The lectures are focussed on the grant writing and reviewing processes, including applications to research ethics committees, how to write a CV and calculate budget, legal aspects and how to write contracts with funding agencies. There will be a hands-on workshop on finding funding opportunities. Time: week 44-45

Aktuell omvårdnadsvetenskap – teori och praxis

Course Number:2097

Credit Points:7,5

Date:29 oct 2007--30 nov 2007

Alla undervisningsmoment, föreläsningar och seminarier under kursen är obligatoriska. Campusbunden undervisning ligger vecka 45 samt två seminariedagar och två examinationsdagar vecka 47 och 48

Course organizer:
Maria Arman Rehnsfeldt
Institutionen för neurovetenskap vårdvetenskap och samhälle
Sektionen för omvårdnad
Maria.arman@ki.se


Contact person:
Annika Larsson
Institutionen för neurovetenskap vårdvetenskap och samhälle
Sektionen för omvårdnad
Phone 08 524 83616
Fax:

Aim:
Kursen syftar till fördjupning i omvårdnadsämnets teoretiska och etiska grunder, samt granskning och värdering av aktuell omvårdnadsvetenskaplig forskning

Contents:
Vetenskapsteoretiska aspekter på omvårdnadsvetenskap
Teoriutveckling och begreppsutveckling inom en vetenskap
Omvårdnadsvetenskapens historia och utveckling fram till idag
Granskning och värdering av aktuell omvårdnadsforskning samt pågående teoriutveckling
Vårdetikens utveckling inom omvårdnad som teori och praxis

Statistics in risk assessment focusing on dose response modelling (*)

Course Number:2099

Credit Points:1,5

Date:12 nov 2007--16 nov 2007

All lectures and computer classes are compulsory. To compensate absence extra home assignments will be distributed.

Course organizer:
Dietrich von Rosen
Biometry and Engineering, Swedish University of Agricultural Sciences

dietrich.von.rosen@bt.slu.se


Contact person:
Johanna Zilliacus
Department of Biosciences and Nutrition

Phone +46 8 58583737
Fax:

Aim:
The aim of the course is to provide knowledge on dose response modelling in risk assessment of chemicals, including the Benchmark Dose method.

Contents:
General basic statistics, dose response models, the Benchmark Dose method, applications of the models and methods in practical computer classes.

Cell and molecular biology for dentists

Course Number:2100

Credit Points:1,5

Date:13 sep 2007--13 dec 2007

Course organizer:
Rachael Sugars
Center for Oral Biology,
Institute of Odontology
Rachael.Sugars@ki.se


Contact person:
Rachael Sugars
Center for Oral Biology
Institute of Odontology
Phone 08 746 02 35
Fax:

Aim:
This course is specifically designed for dentists who are undertaking a PhD or specialisation program, and aims to provide them with a basic foundation in the principles and practices of cell and molecular biology, as a basis for research.

Contents:
Molecular biology terms and definitions
Cell structure and components
Cell cycle
Genetic information and organisation
DNA structure, replication and repair
RNA processing synthesis and splicing
Protein synthesis and targeting
Embryology and organogenesis at a molecular level, focusing on cranial-facial development, amelogenesis, dentinogenesis and osteogenesis
Extracellular matrix interactions and biomineralisation
Immunology a basic introduction
Cancer biology
Stem cells and tissue engineering approaches in dentistry
Tools for analysis Molecular biology / DNA techniques
Cell culture and analysis
Protein analysis

Hörsel- och kommunikationsforskning: Att samverka med samhället

Course Number:2101

Credit Points:1,5

Date:5 nov 2007--29 nov 2007

Obligatorisk närvaro vid samtliga föreläsningar. Vid frånvaro ges en arbetsuppgift som skall redovisas skriftligt.

Course organizer:
Docent Ann-Christin Johnson
CLINTEC
Enheten f Audionomi
ann-christin.johnson@ki.se


Contact person:
Professor Mats Ulfendahl
Institutionen för Klinisk Neurovetenskap
Centrum för hörsel- och kommunikationsforskning
Phone +46 8 5177 63 07
Fax:

Aim:
Kursen syftar till att öka förståelsen av att arbeta med att informera samhället om aktuell forskning samt att ge kunskap om de verktyg som kan användas för detta.

Contents:
Under kursen skall olika vertyg för populärvetenskaplig forskningskommunikations presenteras och diskuteras, exempelvis muntliga presentationer, tryckt informationsmaterial, press-releaser och press-konferenser, web-sidor - allt utifrån både sändarens och mottagarens behov och perspektiv. I kursen ingår presentationer av forskare, brukare (handikapporganisationer o.a.), företrädare för universitet och högskola (exempelvis informationsavdelning och pressekreterare), webdesginers, journalister m.fl. Halva kurstiden sker i form av enskilda gruppövningar och enskilt arbete. Den avslutande examinationen sker i grupp med aktiv feedback från övriga studenter och en panel av mottagare.

The mitochondrion: structure, function and its role in pathology and ageing

Course Number:2102

Credit Points:1,5

Date:22 oct 2007--26 oct 2007

All lectures, demonstrations and group tasks are compulsory. Compensation for absence can be discussed with the course directors.

Course organizer:
Aleksandra Trifunovic, PhD
Department of Laboratory Medicine
Division of Metabolic Diseases
Aleksandra.Trifunovic@ki.se


Contact person:
Rolf Wibom, PhD
Department of Laboratory Medicine
Division of Clinical Chemistry
Phone +46 8 585 827 81
Fax:

Aim:
The aim of this course is to give the participants detailed knowledge on mitochondrial function, structure and role in the living cell, as well as in different pathological states that could arrise from mitochondrial dysfunction.

Contents:
The course includes a full survey of mitochondrial structure, function and genomics, how transcription and translation occurs in mitochondria, the mitochondrial energy production process, the process of apoptosis and how mitochondria co-operate with other systems in the cell. It also gives insight into mitochondrial disorders, symptoms, progress, underlying causes and methods to investigate the disorders. Several patient cases will be thoroughly examined and discussed. Animal models of mitochondrial disorders will be described and discussed, and some of laboratory techniques will be demonstrated.

How genes meet environment: genetics of human complex diseases

Course Number:2104

Credit Points:3

Date:19 nov 2007--5 dec 2007

Course organizer:
Leonid Padyukov
Department of Medicine
Rheumatology Unit
leonid.padyukov@ki,se


Contact person:
Maria Seddighzadeh
Department of Medicine
Rheumatology Unit
Phone +46 8 51776564
Fax:

Aim:
The aim of the course is to facilitate understanding the pathogenesis of human complex diseases and of modern approaches for genetic studies of human complex diseases.

Contents:
Biological/clinical description of human complex diseases
Introduction in molecular genetics of human complex diseases
Introduction in genetic epidemiology of human complex diseases
Methodological approaches and bioinformatics

Speech and Hearing Physiology: from Organ till Cortex

Course Number:2105

Credit Points:3

Date:27 sep 2007--6 dec 2007

Lab demonstrations and discussions in seminar groups are compulsory components.

Course organizer:
Barbara Canlon
Dept of Physiology and Pharmacology

Barbara.Canlon@ki.se


Contact person:
Britta Hammarberg
Dept of Clinical Sciences, Intervention and Technology
Div of Logopedics and Phoniatrics
Phone 0858581543
Fax:

Aim:
The aim of the course is for doctoral students in hearing and communication sciences to acquire deepened/deeper? (Sw. fördjupad) knowledge in speech and hearing physiology, and to get an orientation about methods in physiological research. A further aim of the course is for students to gain knowledge about research in clinical physiology and consequencies of impaired physiological conditions that affect abilities to communicate.

Contents:
Physiology of speech and voice production
Auditory physiology from hair cell to auditory nerve
Cognitive processing of language in production, perception and acquisition
Articulation and sound patterns of speech
Central auditory processing and binaural hearing
Physiology of the vestibular system
Physiology of swallowing
The course will be part time and will consist of lectures and seminars once a week during a period of 10 weeks during the autumn term of 2007. The lectures will take place during late afternoons/evenings. Elective lab demonstrations (2-3) will be given during selected afternoons. Students will focus on different topics in smaller seminar groups.

Toxicology I

Course Number:2106

Credit Points:3

Date:19 nov 2007--7 dec 2007

No compulsory moments.

Course organizer:
Annika Hanberg
Institute of Environmental Medicine
Environmental Health Risk Assessment
annika.hanberg@ki.se


Contact person:
Anna Lena Marcus
Institute of Environmental Medicine
Biochemical toxicology
Phone +46 8 524 875 68
Fax:

Aim:
The course aims at giving students a broad base and an understanding in toxicology concepts, principles and applications.

Contents:
The course will include the following major topics: Principles in toxicology, Toxicokinetics, Methods for toxicity testing and research, Target organ toxicity, Toxic effects, e.g. cancer, genotoxicity and reproductive toxicity, Epidemiology and molecular epidemiology, Risk assessment, methods and applications.

Causal Inference from Longitudinal Data

Course Number:2107

Credit Points:1,5

Date:18 dec 2007--21 dec 2007

Course organizer:
Arvid Sjölander
Medical Epidemiology and Biostatistics
-
arvid.sjolander@ki.se


Contact person:
Camilla Ahlqvist
Medical Epidemiology and Biostatistics
-
Phone +46 8 524 838 69
Fax:

Aim:
1. To provide an introduction to counterfactual theory and methods for causal inference from observational data.
2. To present the latest methodological developments for causal inference (by Robins and others) to an epidemiologic audience.

Contents:
Causal inference from observational data is a key task of biostatistics and of allied sciences such as sociology, education, behavioural sciences, demography, economics, health services research , etc. These disciplines share a methodological framework for causal inference that has been developed over the last decades.

This course presents this unifying causal theory and shows how biostatistical concepts and methods can be understood within this general framework. The course emphasizes conceptualization but also introduces statistical models and methods for time-varying exposures. Specifically, this course strives to a) formally define causal concepts such as causal effect and confounding, b) identify the conditions required to estimate causal effects, and c) use analytical methods that, under those conditions, provide estimates that can be endowed with a causal interpretation. The (causal) methods can be used under less restrictive conditions than the traditional statistical methods. For example, causal methods allow one to estimate the causal effect of a time-varying exposure in the presence of time-dependent confounders that lie on the causal pathway between exposure and outcome.

Inherited cancer syndromes; genes predisposing to malignant disease, diagnosis, carcinogenesis and cancer prevention

Course Number:2110

Credit Points:1,5

Date:12 nov 2007--16 nov 2007

Course organizer:
Annika Lindblom
Dept of Molecular Medicine, CMM
Lindbloms group
annika.lindblom@ki.se


Contact person:
Johanna Skoglund
Dept of Molecular Medicine, CMM
Lindbloms group
Phone +46 8 5177 6251
Fax:

Aim:
To learn about cancer syndromes, genes involved and how they were found, mechanisms for carcinogenesis, current clinical state of the art for these syndromes conerning genetic testing, counseling and prevention programs or available therapy for affected individuals. The students will also learn how the knowledge today was gained as well as where is the front-line of the research in the field.

Contents:
The course will present, in the form of lectures and discussions, syndromes such as; breast/ovarian, colorectal cancer syndromes including FAP and HNPCC and other more rare syndroms involving breast- and colorectal cancer, tumor syndromes such as MEN1-2, NF1-2, DNS and inherited melanomas, Wilms tumor, Renal cancer including VHL, and the heritibility of most known cancers.

Introduction to Medical Anthropology

Course Number:2111

Credit Points:4,5

Date:1 oct 2007--9 nov 2007

Attendance at 4 lectures and 4 seminars is obligatory. Missed seminars are to be made up with written assignments.

Course organizer:
Rebecca Popenoe
Institutionen för neurobiologi, vårdvetenskap och samhälle
Sektionen för omvårdnad
rebecca.popenoe@ki.se


Contact person:
Rebecca Popenoe
Institutionen för neurobiologi, vårdvetenskap och samhälle
Sektionen för omvårdnad
Phone
Fax:

Aim:
The course aims to introduce researchers to the field of medical anthropology by examining the way cultural and social factors structure our understandings and experiences of health, illness, and the health care encounter.

Contents:
The course will take up the following topics:
- The concept of culture
- Qualitative research methods for cultural research
- Crosscultural concepts of the body, health, illness, and family
- Cultural assumptions of Western biomedicine

Endothelial function in autoimmune related Human Atherosclerosis

Course Number:2112

Credit Points:3

Date:1 oct 2007--12 oct 2007

The compulsory parts of the course include, Participation in the practical moments of the course, oral examination and a project report by each group. In order to compensate absence, students will be required to submit an extra written summary of the topics chosen by course director.

Course organizer:
Narinder Gautam (Medicine Doktor)
Department of Medicine.
Department of Medicine, Rheumatology Unit Karolinska University Hospital Huddinge, Karolinska Instit
narinder.gautam@ki.se


Contact person:
Narinder Gautam (Medicine Doktor)
Department of Medicine
Rheumatology Unit,
Phone +46-8-585 89395
Fax:

Aim:
This experimental and theoretical course aims at providing participants the basic theoretical and practical aspects of Human Endothelial dysfunction in autoimmune related Atherosclerosis. This course will provide insights into the principle function of human endothelium in health and disease. Further, this course will offer practical training for culture of human endothelial cells, and introduce the applicability of Human Endothelial culture in understanding a link between autoimmune diseases and Atherosclerosis. In addition, recent progresses made in the field will be discussed.

Contents:
The schedule of this experimental and theoretical course is suggested for two weeks and will be held in English. During the first week of the course, lectures/seminars will illustrate acute and chronic Inflammation, Atherosclerosis, Autoimmune diseases, and the role of endothelial dysfunction in atherosclerosis. These lectures/seminars will be held by invited speakers from Karolinska Institutet and other institutions from Sweden and will be followed by a scientific discussion. The contents of second week of the course are unique. This sequence of laboratory course will be designed to teach students the techniques of endothelial cell culture from human umbilical veins (HUVEC). Students in small groups will culture endothelial cells and receive information regarding culture media, tissue culture (TC-plastics). Students will learn sterile technique, develop their ability to visually assess cell morphology and confluency, and learn how to maintain cells in culture. Using these cells, students will conduct viability, attachment, and proliferation assays. Students will learn serum-dependent vs. serum-free culture conditions, regulation of proliferation, differentiation, cell death and gene expression in vitro. This overview will be followed by a brief discussion about HUVEC culture methodology and its applications to human research linking autoimmunity with Atherosclerosis. A project report and an obligatory oral examination will be held at the end of the course.

Mucosal immunity and infections

Course Number:2113

Credit Points:1,5

Date:8 oct 2007--12 oct 2007

The students are expected to attend all the lectures and seminars held within the course. Also, they are expected to actively participate in the group assignment and presentation plus hand in the written report to successfully complete the course. Single missed sessions may be replaced by written tasks adapted to the situation.

Course organizer:
Taha Hirbod
Department of medicine, Solna
Infectious diseases unit
taha.hirbod@ki.se


Contact person:
Karin Loré
Department of Medicine, Huddinge
Center for Infectious Medicine
Phone +46 8 4572652
Fax:

Aim:

The aim of this course is to expand the students’ knowledge about mucosal immunity and the most common pathogens which target the largest immunological organs in the body.

Contents:

The content of the course may be divided into two parts:
Part I
This part provides an introductory overview on the physiology of the mucosal defense in the genital and gastro intestinal tracts. More specifically, we will address the structure and function of the mucosal epithelium in different compartments and different cell types including cellular basis of antigen transport, innate immune factors, development and function of mucosal immunoglobulin. We will also address the different target and effector sites for the mucosal immune responses.
Part II
In this part of the course, we will address the secretory immune system with special reference to mucosal infections and diseases. We will specifically focus on bacterial and viral infections in the genital tract and the corresponding mucosal immune responses. Finally, we will discuss and explore the field of mucosal immunization and the concepts of mucosal vaccines.

Longitudinal Studies with Qualitative Approach

Course Number:2114

Credit Points:4,5

Date:31 oct 2007--12 dec 2007

Participation in the workshop and the seminars are compulsory.

Course organizer:
Ella Danielson
Department of Health Sciences

Ella.Danielson@miun.se


Contact person:
Malin Lindell
Neurobiology, Care Sciences, and Society
Division of Occupational Therapy
Phone +46 8 524 838 30
Fax:

Aim:
The course aims to support the students to deepen their knowledge about different qualitative approaches and methods for scientific inquiries of processes in health care sciences involving temporal aspects.

Contents:
The course includes lectures by experts in different qualitative approaches and methods for scientific inquiries of processes in health and care sciences involving temporal aspects (content analysis, ethnography, phenomenology and grounded theory). In a workshop the students will practice longitudinal analysis using one qualitative method. In seminars the students will discuss the process and the result of longitudinal analyses and in a final paper present reflections on applying longitudinal designs and methods in their own research in light of the different qualitative approaches that have been presented during the course. Parts of the course will be given in English.

Person based quantitative designs in longitudinal research

Course Number:2115

Credit Points:3

Date:1 oct 2007--30 nov 2007

Taking part of all lectures and seminars is compulsory as well as taking part in final workshop. Absence from video seminars is to be compensated by a two page long written critical discussion of an application of person based longitudinal research approaches in the students own area of research. Absence from final workshop is to be compensated by writing a 5 page long discussion of the other students written papers following final workshop

Course organizer:
Mats Granlund
ISB
Mälardalen University
mats.granlund@hhj.hj.se


Contact person:
Sofie Almers
Jönköping University
School of Health Sciences
Phone +46 36 101185
Fax:

Aim:
To support students in developing in depth knowledge about quantitative longitudinal designs

Contents:
The content is focusing on presenting and discussing the conceptual foundations of person based quantitative longitudinal designs. In addition the lectures will present and discuss applications of person based longitudinal designs in research. Problems in applications that will be discussed include theoretical and practical challenges in choosing variables to include in a person based cluster of variables, choosing variables for growth cure modeling, and handling attrition.>

Neurooftalmologi / Neuroophthalmology

Course Number:2116

Credit Points:7,5

Date:28 jan 2008--6 apr 2008

Course organizer:
Lene Martin
Klinisk neurovetenskap
<Ögon & Syn
lene.martin@ki.se


Contact person:
Lene Martin

Ögon & Syn
Phone <+46 8 672 3668
Fax:

Aim:
The aim of the course is that the student should be able to perform, evaluate and analyze a professional neuro-ophthalmological examination and have knowledge about the common neuro-ophthalmological signs, symptoms and disorders

Contents:
The course starts with an overview of anatomical structures and the physiology of vision and eye motility. This part is followed by a detailed discussion of anatomy and physiology in relation to common disorders and problems in the field of neuro-ophthalmology. The course contains detailed descriptions of both quantitative and qualitative examinations and diagnostic methods. The later part is dedicated to the diagnosis, definition and description of lesions in the vision-related brain areas. Finally, a number of neuro-ophthalmologic syndromes are described.

Commercialising Science Innovation and Entrepreneurship Theory

Course Number:2117

Credit Points:4,5

Date:1 oct 2007--19 oct 2007

All lectures are compulsory.

Course organizer:
Carl Johan Sundberg
LIME
UBE (Unit for Bioentrepreneurship)
carl.j.sundberg@ki.se


Contact person:
Hanna Jansson
LIME
Unit for Bioentrepreneurship (UBE)
Phone +46 8 524 838 61
Fax:

Aim:
The aim of the course is to give the participants a connectional framework and a theoretical understanding for innovation and entrepreneurship with knowledge on how to develop ideas and commercialization in theory and practice. The framing of the course gives the students important contacts within industry, organisations and public sector.

The course will be given at Karolinska Institutet but offered to PhD candidates nationally.

Contents:
The course is divided into four components:
1. Innovation and entrepreneurship: clusters of innovation, universities and their relation to entrepreneurship etc
2. Law and regulations: corporate law, patenting law (European and US perspective) etc
3. Finance: public and private financing of new companies etc
4. Strategy: business plan, collaboration between large and small companies, corporate intelligence, role of boards, human resource management etc

The course is conducted as full-time studies, daytime. The course will include lectures, seminars and case studies. The lectures will be held by experts from industry, academia and other organisations within the fields of innovation, entrepreneurship, patenting and finance. Lectures and seminars will be concentrated to periods in the beginning and end of the course. Other parts of the course will be offered as distance tuition with web based elements to match the national admission.

Commercialising Science Innovation and Entrepreneurship Projects

Course Number:2118

Credit Points:3

Date:5 nov 2007--16 nov 2007

All lectures are compulsory.

Course organizer:
Carl Johan Sundberg
LIME
UBE (Unit for Bioentrepreneurship)
carl.j.sundberg@ki.se


Contact person:
Hanna Jansson
LIME
Unit for Bioentrepreneurship (UBE)
Phone +46 8 524 838 61
Fax:

Aim:
The aim of the course is to give the participants a possibility to go deeper into a specific project and to get profound understanding of the practical applications within innovation and entrepreneurship. The course, will also give the candidates important contacts in industry, organisations as well as the public sector.

The course will be given at Karolinska Institutet but offered to PhD candidates nationally. The course is a continuation of the more theoretically based course Commercialising Science Innovation and Entrepreneurship Theory.

Contents:
Innovation and entrepreneurship in projects, project work in collaboration with the industry/public sector. The participants will have the opportunity to work deeper with an actual problem under an entrepreneurial perspective. The theme of the project lies within innovation, entrepreneurship, patenting and finance. The specific subject is determined together with the course direction in the beginning of the course. The purpose is to give the candidates practical applications on their theoretical knowledge, but also gain their personal network.

The work contents projects in groups or individually, in collaboration with the industry/public sector, where the candidates work deeper with an actual problem. The purpose is to give the candidates practical applications on their theoretical knowledge, but also gain their personal network. The lectures and seminars will be concentrated to periods in the beginning and end of the course. Contact during the course will be held by a web based platform.

Antigen presentation pathways and immune evasion

Course Number:2119

Credit Points:1,5

Date:24 sep 2007--28 sep 2007

All lectures and discussion are considered mandatory. Missed events should be compensated for with a written report on the subject

Course organizer:
Michael Uhlin
MTC
MTC
Michael.uhlin@ki.se


Contact person:
Hanna Sjölin
MTC
MTC
Phone +46852486216
Fax:

Aim:
Antigen presentation mechanisms and immune evasion through targeting of these mechanisms is a still rapidly developing research field. This course will provide the students within the Infection Biology program with a necessary platform and update of these concepts.

Contents:
Course Curriculum

Review articles and specific papers related to the lectures are distributed one week prior to the course.

The following will be covered during the course.
Antigen capture (including endocytosis, phagocytosis) and microbial infection/immune evasion strategies related to this. This will be followed by a thourough walkthrough of the antigen presentation pathways, both MHC class I and II. Terms like altered peptide ligands, cross presentation, TCR recognition and NK cell receptors will be covered.
After this microbial immune evasion targeting antigen presentation pathways
will be discussed and presented.
The CD1 system, presentation of lipids, glycolipids (including microbial interference, presentation to lymphocytes such as CD1 restricted T cells and NKT Cells, lymphocyte mediated regulation of antigen presentation) will also be discussed.
It will be finished off by covering apoptosis: Results of antigen presentation to effector cells, with focus on lymphocyte and target cell apoptosis and survival; signaling pathways and network within the cells.
Ending with a written exam

Infection and Cancer research seminar series

Course Number:2120

Credit Points:3

Date:20 aug 2007--20 dec 2007

Attendance to the seminares and participation in an oral presentation is compulsory. In case of absence the student can compensate with either a written report or an additional presentation.

Course organizer:
Maria Masucci
CMB

maria.masucci@ki.se


Contact person:
Kristina.lindsten@ki.se
Department of Cell and Molecular Biology (CMB)

Phone +46 8 5248 74 67
Fax:

Aim:
The aim of this course is for the students to get an updated overview of the broad research field of cells microbes and cancer.

Contents:
The course is organized to contain approximately 15 seminars/lectures, held by invited speakers partly from the Karolinska Institutet but mainly from other Institutes in Europe. The speakers will be asked to organize their talks to give a comprehensive and pedagocial overview of the research area as well as an in depth discussion on their own research. Each seminar will be followed by a discussion led by the course organizers where the students are encouraged to interact with the invited speaker. To enable a fruitful discussion the students will be given one or several articles, chosen by the speaker, which they will have to read and study carefully beforehand.
In the end of the course the students will give an in depth presentation on a subject within the scope of the course. The preparation and presentation will be performed groupwise in front of all the participants and organizers of the course.

Hypertension - pathophysiology and treatment

Course Number:2125

Credit Points:1,5

Date:19 nov 2007--23 nov 2007

Compulsory parts include 2-3 (afternoon) group works. Absence from group works can be compensated by an individual written report on the subject.

Course organizer:
Rickard Malmström
Dept. Medicine Solna, Clinical Pharmacology Unit
Dept. Medicine Solna, Clinical Pharmacology Unit
rickard.malmstrom@ki.se


Contact person:
Lillemor Melander
Dept. Medicine, Clinical Pharmacology Unit
Dept. Medicine, Clinical Pharmacology Unit
Phone +46 8 51775292
Fax:

Aim:
To review present and future therapy of hypertension in relation to its pathophysiology. To give the participants increased skill in the critical evaluation of clinical studies, including design, performance and interpretation.

Contents:
The schedule will include 4 to 7 lectures per day, in combination with PBL and discussions. Lectures will cover the following fields: Epidemiology and pathophysiology of hypertension. A review of the basic pharmacology of past, present and future antihypertensive drugs. An overview of the methodologies in the assessment of diagnosis and measurement of blood pressure in clinical trials and in clinical praxis. Review, and training in the critical evaluation of clinical trials and observational studies on antihypertensive treatments. Review, and critical evaluation, of present treatment principles in the presence of co-morbidities such as coronary artery, peripheral artery and cerebrovascular disease.
Participants will perform group work where they are trained in critical evaluation of clinical trials of antihypertensive drug treatments. Totally lectures will cover about 50-75% of the teaching hours, the remainder will consist of group work and discussions.

Physiological Methods in Cardiovascular Research in Man

Course Number:2127

Credit Points:1,5

Date:22 oct 2007--26 oct 2007

Course organizer:
Kenneth Caidahl
Molecular medicine and surgery
Thorax kärl
Kenneth.caidahl@ki.se


Contact person:
Eva Brimark
Laboratory medicine
Thorax kärl
Phone
Fax:

Aim:
The PhD student should learn about cardiovascular diagnostic tests that might be applied in scientific studies

Contents:
Methods to measure myocardial, renal, extremity and cerebral blood flow. Methods that will be discussed for vascular studies are occlusion plethysmography, thermo dilution, dye dilution, isotopic clearance, ultrasound/Doppler, positron-emission tomography (PET), magnetic resonance imaging (MRI).
- Central hemodynamics with pressure-flow and pressure-volume relationships. Influence of loading on right and left ventricular function. Myocardial pumping function in longitudinal, transverse and rotational directions. Methods for determination of myocardial perfusion: scintigraphy, PET, MRI and Doppler-echocardiography.
The course will end with a seminar where the participants present their PhD (or an allocated) project and the methods they intend to use will be discussed

Development of the nervous system

Course Number:2128

Credit Points:1,5

Date:10 sep 2007--14 sep 2007

Lectures, discussions and tutorials are obligatory. Absence from the practicals is compensated according to the instructors of the course leader.

Course organizer:
Johan Ericson
Cell and Molecular Biology

johan.ericson@ki.se


Contact person:
Matti Nikkola
Cell and Molecular Biology

Phone 08-524 87398
Fax:

Aim:
The course covers key mechanisms underlying the development of the vertebrate nervous system. The course is organized in collaboration with the research school of DBRM (Strategic Research Center in Developmental Biology for Regenerative Medicine. www.dbrm.se) at Karolinska Institutet. The center and the course are funded by the Linné program at Swedish Research Council

Contents:
The course consists of lectures, discussions and small group tutorials and projects based on recent publications.

Introduction to Protein Structure

Course Number:2129

Credit Points:4,5

Date:24 sep 2007--10 dec 2007

All practical exercises are compulsory. Absence compensation will be discussed on an individual basis as the practicals are directly based on the preceding lecture/seminar.

Course organizer:
Doreen Dobritzsch
Medical Biochemistry and Biophysics
Molecular Structural Biology
Doreen.Dobritzsch@ki.se


Contact person:
Eva Lindberg
Medical Biochemistry and Biophysics
Molecular Structural Biology
Phone +46 8 524 87676
Fax:

Aim:
The course will provide an overview about the principles of protein structure, the methods used to determine protein structures and the relationship between three-dimensional structure and biological function. The course consists of approximately 15 lectures/seminars and practical exercises, and is intended for PhD students and postdoctoral fellows. The topics include lectures on basic principles of protein structure, structure/function and engineering, as well as how one studies protein properties using X-ray crystallography, NMR and structural databases accessible through www.

Contents:
The course consists of approximately 15 lectures/seminars providing the background knowledge, followed by practical exercises in which the students will work with data bases and graphics programs to study and analyse protein structures. The lectures will be held by in-house researchers and invited experts of the field from other Swedish universities. Homework assignments will be used to deepen the gained knowledge and train the students in utilization of data bases, structure modeling and analysis servers and graphics programs.

The lectures will take place every Monday morning the fall semester 2007. The practical exercises, which are compulsory for all students, will follow in the afternoon.


 

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