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In earlier studies on antimicrobial resistance in bacterial pathogens
at a university hospital,
Karolinska, Stockholm, in a twelve
year perspective, as well as at a total of twelve
hospitals in Sweden, we found increasing levels of resistance
to carbapenems.
Christian Giske is further investigating the molecular mechanisms
involved in carbapenem resistance in Pseudomonas aeruginosa, and
in other Gram negative bacterial pathogens.
1.
VIM-4 in a carbapenem-resistant strain of Pseudomonas aeruginosa
isolated in Sweden.
2.
Carbapenem-resistance mechanisms in Pseudomonas aeruginosa: alterations
of porin OprD and efflux proteins do not fully explain resistance
patterns observed in clinical isolates.
3.
Meropenem susceptibility breakpoint for Pseudomonas aeruginosa:
strains hyperproducing mexB mRNA.
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