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ANTIMICROBIAL
RESISTANCE AND RESISTANCE MECHANISMS IN BACTERIAL PATHOGENS
The
main resesarch theme in the laboratory is antimicrobial resistance,
particularly the epidemiology of resistance, the molecular and genetic
basis of resistance, its spread in the community and between bacteria,
and also methodological aspects of antimicrobial susceptibility
testing (e.g. species-related
interpretive breakpoints).
Studies of
antimicrobial resistance over time (1988 - 1999) in our hospital,
Karolinska University hospital, Stockholm, have been performed,
both in relation to consumption and comparing levels in wards and
ICU:s. Similar studies were also performed in 12 different hospitals
covering all different parts of Sweden.
Special studies in the field
of antimicrobial resistance are performed in collaborations with
Mattias Larsson, Torkel Falkenberg and Göran Tomson at IHCAR, Karolinska
institute, particularly regarding antibiotic use and antibiotic
resistance in Vietnam and in Latin America. These studies have
shown an extensive overuse of antibiotics and high resistance rates
among common respiratory tract pathogens in Vietnamese children.
In the South American studies (project ANTRES) we use a newly
extended screening method for detecting resistance in both the
dominant faecal flora and in rare clones.
A previous line of research focused
on bacterial proteins binding human and/or animal proteins and their
role in pathogenesis, receptin
research. Plasminogen/plasmin receptins
in H.pylori have been studied in recent years.
Other hospital staff members
in Clinical
microbiology at the division of Clinical microbiology, Karolinska
laboratory, pursue scientific research related to their clinical
responsibilities and interests.
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